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Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients

PURPOSE: To investigate the non-cancer causes of death (COD) in cancer patients with synchronous bone metastasis (BM) that is based on the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: The retrospective cohort study included malignant cancer patients with synchronous BM diagn...

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Autores principales: Xu, Yao, Abdelazeem, Basel, Abbas, Kirellos Said, Lin, Yile, Wu, Haixiao, Zhou, Fei, Peltzer, Karl, Chekhonin, Vladimir P., Li, Shu, Li, Huiyang, Ma, Wenjuan, Zhang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201113/
https://www.ncbi.nlm.nih.gov/pubmed/35721072
http://dx.doi.org/10.3389/fmed.2022.899544
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author Xu, Yao
Abdelazeem, Basel
Abbas, Kirellos Said
Lin, Yile
Wu, Haixiao
Zhou, Fei
Peltzer, Karl
Chekhonin, Vladimir P.
Li, Shu
Li, Huiyang
Ma, Wenjuan
Zhang, Chao
author_facet Xu, Yao
Abdelazeem, Basel
Abbas, Kirellos Said
Lin, Yile
Wu, Haixiao
Zhou, Fei
Peltzer, Karl
Chekhonin, Vladimir P.
Li, Shu
Li, Huiyang
Ma, Wenjuan
Zhang, Chao
author_sort Xu, Yao
collection PubMed
description PURPOSE: To investigate the non-cancer causes of death (COD) in cancer patients with synchronous bone metastasis (BM) that is based on the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: The retrospective cohort study included malignant cancer patients with synchronous BM diagnosed from 2010 to 2018 in the SEER database. The frequencies and proportion of non-cancer COD were calculated and analyzed in different genders, ages, and races subgroups. RESULTS: A total of 97,997 patients were deceased and included into the current study and 6,782 patients were died of non-cancer causes with a male predominance (N = 4,515, 66.6%). Around half of deaths (N = 3,254, 48.0%) occurred within 6 months after diagnosis while 721 patients were deceased after 3 years. Lung and bronchus cancer, prostate cancer, breast cancer, kidney and renal pelvis cancer, and liver cancer were proved to be the top five cancer types resulting in non-cancer caused death. Cardiovascular and cerebrovascular diseases were the leading non-cancer cause of death (N = 2,618), followed by COPD and associated conditions (N = 553) and septicemia, infectious and parasitic diseases (N = 544). Sub-analyses stratified by gender, age and race were performed and the similar results with slightly difference were observed. CONCLUSIONS: Cardiovascular and cerebrovascular diseases were the main non-cancer cause of death in cancer patients with synchronous BM. Other non-cancer causes included COPD, septicemia, infectious and parasitic diseases, and so on. These findings should be considered by physicians. Physicians can counsel cancer patients with BM regarding survivorship with death causes screening and focus on prevention of non-cancer deaths.
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spelling pubmed-92011132022-06-17 Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients Xu, Yao Abdelazeem, Basel Abbas, Kirellos Said Lin, Yile Wu, Haixiao Zhou, Fei Peltzer, Karl Chekhonin, Vladimir P. Li, Shu Li, Huiyang Ma, Wenjuan Zhang, Chao Front Med (Lausanne) Medicine PURPOSE: To investigate the non-cancer causes of death (COD) in cancer patients with synchronous bone metastasis (BM) that is based on the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: The retrospective cohort study included malignant cancer patients with synchronous BM diagnosed from 2010 to 2018 in the SEER database. The frequencies and proportion of non-cancer COD were calculated and analyzed in different genders, ages, and races subgroups. RESULTS: A total of 97,997 patients were deceased and included into the current study and 6,782 patients were died of non-cancer causes with a male predominance (N = 4,515, 66.6%). Around half of deaths (N = 3,254, 48.0%) occurred within 6 months after diagnosis while 721 patients were deceased after 3 years. Lung and bronchus cancer, prostate cancer, breast cancer, kidney and renal pelvis cancer, and liver cancer were proved to be the top five cancer types resulting in non-cancer caused death. Cardiovascular and cerebrovascular diseases were the leading non-cancer cause of death (N = 2,618), followed by COPD and associated conditions (N = 553) and septicemia, infectious and parasitic diseases (N = 544). Sub-analyses stratified by gender, age and race were performed and the similar results with slightly difference were observed. CONCLUSIONS: Cardiovascular and cerebrovascular diseases were the main non-cancer cause of death in cancer patients with synchronous BM. Other non-cancer causes included COPD, septicemia, infectious and parasitic diseases, and so on. These findings should be considered by physicians. Physicians can counsel cancer patients with BM regarding survivorship with death causes screening and focus on prevention of non-cancer deaths. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9201113/ /pubmed/35721072 http://dx.doi.org/10.3389/fmed.2022.899544 Text en Copyright © 2022 Xu, Abdelazeem, Abbas, Lin, Wu, Zhou, Peltzer, Chekhonin, Li, Li, Ma and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Xu, Yao
Abdelazeem, Basel
Abbas, Kirellos Said
Lin, Yile
Wu, Haixiao
Zhou, Fei
Peltzer, Karl
Chekhonin, Vladimir P.
Li, Shu
Li, Huiyang
Ma, Wenjuan
Zhang, Chao
Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients
title Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients
title_full Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients
title_fullStr Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients
title_full_unstemmed Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients
title_short Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients
title_sort non-cancer causes of death following initial synchronous bone metastasis in cancer patients
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201113/
https://www.ncbi.nlm.nih.gov/pubmed/35721072
http://dx.doi.org/10.3389/fmed.2022.899544
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