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A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review
BACKGROUND: Mycobacterium chelonae (M. chelonae) empyema complicated with bronchopleural fistula (BPF) remains a significant challenge in diagnosis and treatment and the clinical outcomes are often unsatisfactory, especially in elderly patients. There is a paucity data related to the management of t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201175/ https://www.ncbi.nlm.nih.gov/pubmed/35722409 http://dx.doi.org/10.21037/atm-22-2130 |
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author | Liu, Xiaolong Huang, Zhihua Luo, Shaohua Yang, Shifang Huang, Junwei Chen, Pingping Lin, Qi Wu, Jian |
author_facet | Liu, Xiaolong Huang, Zhihua Luo, Shaohua Yang, Shifang Huang, Junwei Chen, Pingping Lin, Qi Wu, Jian |
author_sort | Liu, Xiaolong |
collection | PubMed |
description | BACKGROUND: Mycobacterium chelonae (M. chelonae) empyema complicated with bronchopleural fistula (BPF) remains a significant challenge in diagnosis and treatment and the clinical outcomes are often unsatisfactory, especially in elderly patients. There is a paucity data related to the management of the condition. This is the first well-documented report of the therapeutic experience with bronchoscopic closure of a bronchopleural fistula with empyema related to M. chelonae infection in the elderly patients. CASE DESCRIPTION: An 86-year-old non-smoking male with a history of diabetes mellitus, emphysema, and bronchiectasis, and a 72-year-old non-smoking male with two past surgeries for lung cancer, both presented with chronic fever, purulent expectoration, hemoptysis, and dyspnea, and were diagnosed with bronchopleural fistula associated with M. chelonae infection. Long-term antibiotic regimens, prolonged thoracic drainage, and endoscopic closure with biological glue were all unsuccessful. The culprit bronchus was identified precisely with the combined assistance of the instillation of methylene blue and the Chartis digital air leak monitoring system. Bronchoscopic interventional therapy was successfully performed using the Zephyr one-way endobronchial valve or the Amplatzer patent ductus arteriosus occluder. Finally, two patients succeeded in removing chest tube, and were able to conduct daily activities. CONCLUSIONS: The successful bronchoscopic closure with the combined assistance of methylene blue and the Chartis digital air leak monitoring system provided valuable experience and novel strategy in dealing with BPF related to M. chelonae in the elderly and high-risk inoperable patients. |
format | Online Article Text |
id | pubmed-9201175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-92011752022-06-17 A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review Liu, Xiaolong Huang, Zhihua Luo, Shaohua Yang, Shifang Huang, Junwei Chen, Pingping Lin, Qi Wu, Jian Ann Transl Med Case Report BACKGROUND: Mycobacterium chelonae (M. chelonae) empyema complicated with bronchopleural fistula (BPF) remains a significant challenge in diagnosis and treatment and the clinical outcomes are often unsatisfactory, especially in elderly patients. There is a paucity data related to the management of the condition. This is the first well-documented report of the therapeutic experience with bronchoscopic closure of a bronchopleural fistula with empyema related to M. chelonae infection in the elderly patients. CASE DESCRIPTION: An 86-year-old non-smoking male with a history of diabetes mellitus, emphysema, and bronchiectasis, and a 72-year-old non-smoking male with two past surgeries for lung cancer, both presented with chronic fever, purulent expectoration, hemoptysis, and dyspnea, and were diagnosed with bronchopleural fistula associated with M. chelonae infection. Long-term antibiotic regimens, prolonged thoracic drainage, and endoscopic closure with biological glue were all unsuccessful. The culprit bronchus was identified precisely with the combined assistance of the instillation of methylene blue and the Chartis digital air leak monitoring system. Bronchoscopic interventional therapy was successfully performed using the Zephyr one-way endobronchial valve or the Amplatzer patent ductus arteriosus occluder. Finally, two patients succeeded in removing chest tube, and were able to conduct daily activities. CONCLUSIONS: The successful bronchoscopic closure with the combined assistance of methylene blue and the Chartis digital air leak monitoring system provided valuable experience and novel strategy in dealing with BPF related to M. chelonae in the elderly and high-risk inoperable patients. AME Publishing Company 2022-05 /pmc/articles/PMC9201175/ /pubmed/35722409 http://dx.doi.org/10.21037/atm-22-2130 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Case Report Liu, Xiaolong Huang, Zhihua Luo, Shaohua Yang, Shifang Huang, Junwei Chen, Pingping Lin, Qi Wu, Jian A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review |
title | A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review |
title_full | A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review |
title_fullStr | A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review |
title_full_unstemmed | A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review |
title_short | A novel therapeutic strategy to close bronchopleural fistula related to Mycobacterium chelonae in elderly patients: two case reports and literature review |
title_sort | novel therapeutic strategy to close bronchopleural fistula related to mycobacterium chelonae in elderly patients: two case reports and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201175/ https://www.ncbi.nlm.nih.gov/pubmed/35722409 http://dx.doi.org/10.21037/atm-22-2130 |
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