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Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial
BACKGROUND: The aim of this study was to compare the effect of adding oral clonidine to standard treatments on pain intensity in patients with acute renal colic. MATERIALS AND METHODS: This is a randomized clinical trial that was performed in 2020 in Isfahan. The study population consisted of 200 pa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201228/ https://www.ncbi.nlm.nih.gov/pubmed/35720212 http://dx.doi.org/10.4103/abr.abr_2_21 |
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author | Esmailian, Mehrdad Golshani, Keihan Tavakolifard, Negah Amiri, Alireza |
author_facet | Esmailian, Mehrdad Golshani, Keihan Tavakolifard, Negah Amiri, Alireza |
author_sort | Esmailian, Mehrdad |
collection | PubMed |
description | BACKGROUND: The aim of this study was to compare the effect of adding oral clonidine to standard treatments on pain intensity in patients with acute renal colic. MATERIALS AND METHODS: This is a randomized clinical trial that was performed in 2020 in Isfahan. The study population consisted of 200 patients with renal colic. Pain of the patients was assessed using Visual Analog Scale. Patients were then randomized into 4 groups of 50 patients. Group A received 0.1 mg/kg morphine and clonidine tablets (0.2 mg). Group B received morphine and placebo. Group C received 30 mg ketorolac and clonidine tablets. Group D received 30 mg ketorolac and placebo tablets. Pain of patients was assessed. 0.05 mg/kg morphine was administered and repeated every 40 min if the pain was not reduced. RESULTS: Our data showed that there was a significant difference between pains of patient by the time of admission in groups (P = 0.04). However, no significant differences were observed between pains of patients in different measuring times (P > 0.05). Using general linear model, we showed that the decreases in pain scores of each group were significant (P < 0.05) but there were no significant differences in pains of patients in different measuring times (P > 0.05). Our data showed that Group A and Group C had lowest frequencies of morphine administrations while Groups B and D had the highest frequencies (P < 0.001). CONCLUSION: We showed that administration of clonidine in patients with renal colic resulted in better pain control and lower morphine injections. |
format | Online Article Text |
id | pubmed-9201228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-92012282022-06-17 Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial Esmailian, Mehrdad Golshani, Keihan Tavakolifard, Negah Amiri, Alireza Adv Biomed Res Original Article BACKGROUND: The aim of this study was to compare the effect of adding oral clonidine to standard treatments on pain intensity in patients with acute renal colic. MATERIALS AND METHODS: This is a randomized clinical trial that was performed in 2020 in Isfahan. The study population consisted of 200 patients with renal colic. Pain of the patients was assessed using Visual Analog Scale. Patients were then randomized into 4 groups of 50 patients. Group A received 0.1 mg/kg morphine and clonidine tablets (0.2 mg). Group B received morphine and placebo. Group C received 30 mg ketorolac and clonidine tablets. Group D received 30 mg ketorolac and placebo tablets. Pain of patients was assessed. 0.05 mg/kg morphine was administered and repeated every 40 min if the pain was not reduced. RESULTS: Our data showed that there was a significant difference between pains of patient by the time of admission in groups (P = 0.04). However, no significant differences were observed between pains of patients in different measuring times (P > 0.05). Using general linear model, we showed that the decreases in pain scores of each group were significant (P < 0.05) but there were no significant differences in pains of patients in different measuring times (P > 0.05). Our data showed that Group A and Group C had lowest frequencies of morphine administrations while Groups B and D had the highest frequencies (P < 0.001). CONCLUSION: We showed that administration of clonidine in patients with renal colic resulted in better pain control and lower morphine injections. Wolters Kluwer - Medknow 2022-04-29 /pmc/articles/PMC9201228/ /pubmed/35720212 http://dx.doi.org/10.4103/abr.abr_2_21 Text en Copyright: © 2022 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Esmailian, Mehrdad Golshani, Keihan Tavakolifard, Negah Amiri, Alireza Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial |
title | Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial |
title_full | Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial |
title_fullStr | Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial |
title_full_unstemmed | Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial |
title_short | Effects of Adding Oral Clonidine to Standard Treatments on Pain Intensity of Patients with Acute Renal Colic: A Randomized Clinical Trial |
title_sort | effects of adding oral clonidine to standard treatments on pain intensity of patients with acute renal colic: a randomized clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201228/ https://www.ncbi.nlm.nih.gov/pubmed/35720212 http://dx.doi.org/10.4103/abr.abr_2_21 |
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