Structure-based design and synthesis of a novel long-chain 4′′-alkyl ether derivative of EGCG as potent EGFR inhibitor: in vitro and in silico studies

Herein, we report the discovery of a novel long-chain ether derivative of (−)-epigallocatechin-3-gallate (EGCG), a major green tea polyphenol as a potent EGFR inhibitor. A series of 4′′-alkyl EGCG derivatives have been synthesized via regio-selectively alkylating the 4′′ hydroxyl group in the D-ring...

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Detalles Bibliográficos
Autores principales: Singh, Satyam, Sahadevan, Revathy, Roy, Rajarshi, Biswas, Mainak, Ghosh, Priya, Kar, Parimal, Sonawane, Avinash, Sadhukhan, Sushabhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201511/
https://www.ncbi.nlm.nih.gov/pubmed/35765335
http://dx.doi.org/10.1039/d2ra01919a

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