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Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype

Although brain gray matter (GM) plastically changes during short-term training, it is still unclear whether brain structures are stable for short periods (several months). Therefore, this study aimed to re-test the short-term variability of GM volumes and to clarify the effect of factors (gender and...

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Autores principales: Watanabe, Hiraku, Kojima, Sho, Nagasaka, Kazuaki, Ohno, Ken, Sakurai, Noriko, Kodama, Naoki, Otsuru, Naofumi, Onishi, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201594/
https://www.ncbi.nlm.nih.gov/pubmed/34635909
http://dx.doi.org/10.1093/cercor/bhab370
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author Watanabe, Hiraku
Kojima, Sho
Nagasaka, Kazuaki
Ohno, Ken
Sakurai, Noriko
Kodama, Naoki
Otsuru, Naofumi
Onishi, Hideaki
author_facet Watanabe, Hiraku
Kojima, Sho
Nagasaka, Kazuaki
Ohno, Ken
Sakurai, Noriko
Kodama, Naoki
Otsuru, Naofumi
Onishi, Hideaki
author_sort Watanabe, Hiraku
collection PubMed
description Although brain gray matter (GM) plastically changes during short-term training, it is still unclear whether brain structures are stable for short periods (several months). Therefore, this study aimed to re-test the short-term variability of GM volumes and to clarify the effect of factors (gender and BDNF-genotype) expected to contribute to such variability. The subjects comprised 41 young healthy adults. T1-weighted images were acquired twice with an interval of approximately 4 months using a 3 T-MRI scanner. Voxel-based morphometry (VBM) was used to calculate GM volumes in 47 regions. The intraclass correlation coefficient (ICC) and Test–retest variability (%TRV) were used as indices of variability. As a result, the ICCs in 43 regions were excellent (ICC > 0.90) and those in 3 regions were good (ICC > 0.80), whereas the ICC in the thalamus was moderate (ICC = 0.694). Women had a higher %TRV than men in 5 regions, and %TRV of the Val66Val group was higher than that of the Met carrier group in 2 regions. Moreover, the Female-Val66Val group had a higher %TRV than the Male-Met carrier group in 3 regions. These results indicate that although the short-term variability of GM volumes is small, it is affected by within-subject factors.
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spelling pubmed-92015942022-06-16 Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype Watanabe, Hiraku Kojima, Sho Nagasaka, Kazuaki Ohno, Ken Sakurai, Noriko Kodama, Naoki Otsuru, Naofumi Onishi, Hideaki Cereb Cortex Original Article Although brain gray matter (GM) plastically changes during short-term training, it is still unclear whether brain structures are stable for short periods (several months). Therefore, this study aimed to re-test the short-term variability of GM volumes and to clarify the effect of factors (gender and BDNF-genotype) expected to contribute to such variability. The subjects comprised 41 young healthy adults. T1-weighted images were acquired twice with an interval of approximately 4 months using a 3 T-MRI scanner. Voxel-based morphometry (VBM) was used to calculate GM volumes in 47 regions. The intraclass correlation coefficient (ICC) and Test–retest variability (%TRV) were used as indices of variability. As a result, the ICCs in 43 regions were excellent (ICC > 0.90) and those in 3 regions were good (ICC > 0.80), whereas the ICC in the thalamus was moderate (ICC = 0.694). Women had a higher %TRV than men in 5 regions, and %TRV of the Val66Val group was higher than that of the Met carrier group in 2 regions. Moreover, the Female-Val66Val group had a higher %TRV than the Male-Met carrier group in 3 regions. These results indicate that although the short-term variability of GM volumes is small, it is affected by within-subject factors. Oxford University Press 2021-10-11 /pmc/articles/PMC9201594/ /pubmed/34635909 http://dx.doi.org/10.1093/cercor/bhab370 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Watanabe, Hiraku
Kojima, Sho
Nagasaka, Kazuaki
Ohno, Ken
Sakurai, Noriko
Kodama, Naoki
Otsuru, Naofumi
Onishi, Hideaki
Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
title Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
title_full Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
title_fullStr Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
title_full_unstemmed Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
title_short Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
title_sort gray matter volume variability in young healthy adults: influence of gender difference and brain-derived neurotrophic factor genotype
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201594/
https://www.ncbi.nlm.nih.gov/pubmed/34635909
http://dx.doi.org/10.1093/cercor/bhab370
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