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Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion
Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how these func...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201596/ https://www.ncbi.nlm.nih.gov/pubmed/34689209 http://dx.doi.org/10.1093/cercor/bhab373 |
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author | West, Sarah L Aronson, Justin D Popa, Laurentiu S Feller, Kathryn D Carter, Russell E Chiesl, William M Gerhart, Morgan L Shekhar, Aditya C Ghanbari, Leila Kodandaramaiah, Suhasa B Ebner, Timothy J |
author_facet | West, Sarah L Aronson, Justin D Popa, Laurentiu S Feller, Kathryn D Carter, Russell E Chiesl, William M Gerhart, Morgan L Shekhar, Aditya C Ghanbari, Leila Kodandaramaiah, Suhasa B Ebner, Timothy J |
author_sort | West, Sarah L |
collection | PubMed |
description | Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how these functional interactions change with behavioral state. Mesoscopic Ca(2+) imaging through transparent polymer skulls in mice reveals elevated activation of the dorsal cerebral cortex during locomotion(.) Using the correlations between the time series of Ca(2+) fluorescence from 28 regions (nodes) obtained using spatial independent component analysis (sICA), we examined the changes in functional connectivity of the cortex from rest to locomotion with a goal of understanding the changes to the cortical functional state that facilitate locomotion. Both the transitions from rest to locomotion and from locomotion to rest show marked increases in correlation among most nodes. However, once a steady state of continued locomotion is reached, many nodes, including primary motor and somatosensory nodes, show decreases in correlations, while retrosplenial and the most anterior nodes of the secondary motor cortex show increases. These results highlight the changes in functional connectivity in the cerebral cortex, representing a series of changes in the cortical state from rest to locomotion and on return to rest. |
format | Online Article Text |
id | pubmed-9201596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92015962022-06-16 Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion West, Sarah L Aronson, Justin D Popa, Laurentiu S Feller, Kathryn D Carter, Russell E Chiesl, William M Gerhart, Morgan L Shekhar, Aditya C Ghanbari, Leila Kodandaramaiah, Suhasa B Ebner, Timothy J Cereb Cortex Original Article Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how these functional interactions change with behavioral state. Mesoscopic Ca(2+) imaging through transparent polymer skulls in mice reveals elevated activation of the dorsal cerebral cortex during locomotion(.) Using the correlations between the time series of Ca(2+) fluorescence from 28 regions (nodes) obtained using spatial independent component analysis (sICA), we examined the changes in functional connectivity of the cortex from rest to locomotion with a goal of understanding the changes to the cortical functional state that facilitate locomotion. Both the transitions from rest to locomotion and from locomotion to rest show marked increases in correlation among most nodes. However, once a steady state of continued locomotion is reached, many nodes, including primary motor and somatosensory nodes, show decreases in correlations, while retrosplenial and the most anterior nodes of the secondary motor cortex show increases. These results highlight the changes in functional connectivity in the cerebral cortex, representing a series of changes in the cortical state from rest to locomotion and on return to rest. Oxford University Press 2021-10-23 /pmc/articles/PMC9201596/ /pubmed/34689209 http://dx.doi.org/10.1093/cercor/bhab373 Text en © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article West, Sarah L Aronson, Justin D Popa, Laurentiu S Feller, Kathryn D Carter, Russell E Chiesl, William M Gerhart, Morgan L Shekhar, Aditya C Ghanbari, Leila Kodandaramaiah, Suhasa B Ebner, Timothy J Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion |
title | Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion |
title_full | Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion |
title_fullStr | Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion |
title_full_unstemmed | Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion |
title_short | Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion |
title_sort | wide-field calcium imaging of dynamic cortical networks during locomotion |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201596/ https://www.ncbi.nlm.nih.gov/pubmed/34689209 http://dx.doi.org/10.1093/cercor/bhab373 |
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