SETD4-mediated KU70 methylation suppresses apoptosis

The mammalian KU70 is a pleiotropic protein functioning in DNA repair and cytoplasmic suppression of apoptosis. We report a regulatory mechanism by which KU70’s cytoplasmic function is enabled due to a methylation at K570 of KU70 by SET-domain-containing protein 4 (SETD4). While SETD4 silencing redu...

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Detalles Bibliográficos
Autores principales: Wang, Yuan, Liu, Bochao, Lu, Huimei, Liu, Jingmei, Romanienko, Peter J., Montelione, Gaetano T., Shen, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201767/
https://www.ncbi.nlm.nih.gov/pubmed/35545041
http://dx.doi.org/10.1016/j.celrep.2022.110794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201767/
https://www.ncbi.nlm.nih.gov/pubmed/35545041
http://dx.doi.org/10.1016/j.celrep.2022.110794

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