Cargando…
Identifying RO9021 as a Potential Inhibitor of PknG from Mycobacterium tuberculosis: Combinative Computational and In Vitro Studies
[Image: see text] Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). Despite being considered curable and preventable, the increase of antibiotic resistance is becoming a serious public health problem. Mtb is a pathogen capable of surviving in macrophages, causing...
Autores principales: | Arica-Sosa, Alicia, Alcántara, Roberto, Jiménez-Avalos, Gabriel, Zimic, Mirko, Milón, Pohl, Quiliano, Miguel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201901/ https://www.ncbi.nlm.nih.gov/pubmed/35721990 http://dx.doi.org/10.1021/acsomega.2c02093 |
Ejemplares similares
-
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis
por: Rieck, Barbara, et al.
Publicado: (2017) -
Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis
por: Santhi, Natchimuthu, et al.
Publicado: (2011) -
Identification of Novel Physiological Substrates of Mycobacterium bovis BCG Protein Kinase G (PknG) by Label-free Quantitative Phosphoproteomics
por: Nakedi, Kehilwe C., et al.
Publicado: (2018) -
Downregulation of protein kinase C-α enhances intracellular survival of Mycobacteria: role of PknG
por: Chaurasiya, Shivendra K, et al.
Publicado: (2009) -
Mycobacterium bovis PknG R242P Mutation Results in Structural Changes with Enhanced Virulence in the Mouse Model of Infection
por: de Oliveira, Fábio Muniz, et al.
Publicado: (2022)