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Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients
In the case of the COVID-19 early diagnosis, numerous tech innovations have been introduced, and many are currently employed worldwide. But, all of the medical procedures for the treatment of this disease, up to now, are just limited to chemical drugs. All of the scientists believe that the major ch...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201910/ https://www.ncbi.nlm.nih.gov/pubmed/35721862 http://dx.doi.org/10.3389/fbioe.2022.850571 |
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author | Abadijoo, Hamed Khayamian, Mohammad Ali Faramarzpour, Mahsa Ghaderinia, Mohammadreza Simaee, Hossein Shalileh, Shahriar Yazdanparast, Seyed Mojtaba Ghabraie, Bahman Makarem, Jalil Sarrami-Forooshani, Ramin Abdolahad, Mohammad |
author_facet | Abadijoo, Hamed Khayamian, Mohammad Ali Faramarzpour, Mahsa Ghaderinia, Mohammadreza Simaee, Hossein Shalileh, Shahriar Yazdanparast, Seyed Mojtaba Ghabraie, Bahman Makarem, Jalil Sarrami-Forooshani, Ramin Abdolahad, Mohammad |
author_sort | Abadijoo, Hamed |
collection | PubMed |
description | In the case of the COVID-19 early diagnosis, numerous tech innovations have been introduced, and many are currently employed worldwide. But, all of the medical procedures for the treatment of this disease, up to now, are just limited to chemical drugs. All of the scientists believe that the major challenge toward the mortality of the COVID-19 patients is the out-of-control immune system activation and the subsequent cytokine production. During this process, the adaptive immune system is highly activated, and many of the lymphocytes start to clonally expand; hence many cytokines are also released. So, any attempt to harness this cytokine storm and calm down the immune outrage is appreciated. While the battleground for the immune hyperactivation is the lung ambient of the infected patients, the only medical treatment for suppressing the hypercytokinemia is based on the immunosuppressor drugs that systemically dampen the immunity with many unavoidable side effects. Here, we applied the alternating electric field to suppress the expansion of the highly activated lymphocytes, and by reducing the number of the renewed cells, the produced cytokines were also decreased. Applying this method to the blood of the COVID-19 patients in vitro showed ∼33% reduction in the average concentration of the three main cytokines after 4 days of stimulation. This method could carefully be utilized to locally suppress the hyperactivated immune cells in the lung of the COVID-19 patients without any need for systemic suppression of the immune system by the chemical drugs. |
format | Online Article Text |
id | pubmed-9201910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92019102022-06-17 Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients Abadijoo, Hamed Khayamian, Mohammad Ali Faramarzpour, Mahsa Ghaderinia, Mohammadreza Simaee, Hossein Shalileh, Shahriar Yazdanparast, Seyed Mojtaba Ghabraie, Bahman Makarem, Jalil Sarrami-Forooshani, Ramin Abdolahad, Mohammad Front Bioeng Biotechnol Bioengineering and Biotechnology In the case of the COVID-19 early diagnosis, numerous tech innovations have been introduced, and many are currently employed worldwide. But, all of the medical procedures for the treatment of this disease, up to now, are just limited to chemical drugs. All of the scientists believe that the major challenge toward the mortality of the COVID-19 patients is the out-of-control immune system activation and the subsequent cytokine production. During this process, the adaptive immune system is highly activated, and many of the lymphocytes start to clonally expand; hence many cytokines are also released. So, any attempt to harness this cytokine storm and calm down the immune outrage is appreciated. While the battleground for the immune hyperactivation is the lung ambient of the infected patients, the only medical treatment for suppressing the hypercytokinemia is based on the immunosuppressor drugs that systemically dampen the immunity with many unavoidable side effects. Here, we applied the alternating electric field to suppress the expansion of the highly activated lymphocytes, and by reducing the number of the renewed cells, the produced cytokines were also decreased. Applying this method to the blood of the COVID-19 patients in vitro showed ∼33% reduction in the average concentration of the three main cytokines after 4 days of stimulation. This method could carefully be utilized to locally suppress the hyperactivated immune cells in the lung of the COVID-19 patients without any need for systemic suppression of the immune system by the chemical drugs. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9201910/ /pubmed/35721862 http://dx.doi.org/10.3389/fbioe.2022.850571 Text en Copyright © 2022 Abadijoo, Khayamian, Faramarzpour, Ghaderinia, Simaee, Shalileh, Yazdanparast, Ghabraie, Makarem, Sarrami-Forooshani and Abdolahad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Abadijoo, Hamed Khayamian, Mohammad Ali Faramarzpour, Mahsa Ghaderinia, Mohammadreza Simaee, Hossein Shalileh, Shahriar Yazdanparast, Seyed Mojtaba Ghabraie, Bahman Makarem, Jalil Sarrami-Forooshani, Ramin Abdolahad, Mohammad Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients |
title | Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients |
title_full | Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients |
title_fullStr | Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients |
title_full_unstemmed | Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients |
title_short | Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients |
title_sort | healing field: using alternating electric fields to prevent cytokine storm by suppressing clonal expansion of the activated lymphocytes in the blood sample of the covid-19 patients |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201910/ https://www.ncbi.nlm.nih.gov/pubmed/35721862 http://dx.doi.org/10.3389/fbioe.2022.850571 |
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