Artesunate Therapy Alleviates Fracture-Associated Chronic Pain After Orthopedic Surgery by Suppressing CCL21-Dependent TREM2/DAP12 Inflammatory Signaling in Mice

Chronic pain after bone fracture and orthopedic surgery is often refractory to most analgesics currently in use, thus emphasizing the urgent need for improved therapeutic medications. Chemokine-dependent neuroinflammation is critical for excitatory synaptic plasticity and central nociception sensiti...

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Detalles Bibliográficos
Autores principales: Zhang, Linlin, Li, Nan, Zhang, Haoyue, Wang, Yigang, Gao, Tianyu, Zhao, Yuying, Wang, Guolin, Yu, Yonghao, Wang, Chunyan, Li, Yize
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202025/
https://www.ncbi.nlm.nih.gov/pubmed/35721188
http://dx.doi.org/10.3389/fphar.2022.894963

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