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FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population
BACKGROUND: Fat mass and obesity-related (FTO) mRNA was downregulated in osteonecrosis patients. The study aimed to evaluate the correlation between FTO polymorphisms and the susceptibility of osteonecrosis of the femoral head (ONFH). METHODS: Six polymorphisms in FTO were genotyped via the Agena Ma...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202150/ https://www.ncbi.nlm.nih.gov/pubmed/35706030 http://dx.doi.org/10.1186/s12920-022-01283-z |
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author | Wang, Yuan Zhong, Wei Wang, Shaofeng Yang, Yang Zhu, Bing |
author_facet | Wang, Yuan Zhong, Wei Wang, Shaofeng Yang, Yang Zhu, Bing |
author_sort | Wang, Yuan |
collection | PubMed |
description | BACKGROUND: Fat mass and obesity-related (FTO) mRNA was downregulated in osteonecrosis patients. The study aimed to evaluate the correlation between FTO polymorphisms and the susceptibility of osteonecrosis of the femoral head (ONFH). METHODS: Six polymorphisms in FTO were genotyped via the Agena MassARRAY in 498 ONFH patients and 498 healthy controls. Multiple genetic models were used to assess the correlation between FTO polymorphisms and ONFH risk by SNPStats. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a logistic regression model adjusted by age, gender, smoking and drinking. RESULTS: The risk-increasing association of rs62033406 A>G with ONFH was found (OR = 1.25, 95% CI 1.05–1.50, p = 0.014). Specially, FTO rs62033406 A>G was related to the risk of ONFH in the subgroup at age > 51 years (OR = 1.25, p = 4.00 × 10(–4)), females (OR = 1.74, p = 1.00 × 10(–4)), smokers (OR = 1.82, p = 0.005) and drinkers (OR = 1.89, p = 0.002), respectively. The best multi–loci model was the five–loci model, a combination of rs9930333 T>G, rs1558902 T>A, rs56094641 A>G, rs3751812 G>T, and rs62033406 A>G (testing accuracy, 0.5351; p = 0.0004; cross–validation consistency, 10/10). CONCLUSION: Our study first revealed that FTO rs62033406 A>G was a risk factor for ONFH among the Chinese Han population, which might provide the new candidate gene for elucidating the pathogenesis of ONFH. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01283-z. |
format | Online Article Text |
id | pubmed-9202150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92021502022-06-17 FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population Wang, Yuan Zhong, Wei Wang, Shaofeng Yang, Yang Zhu, Bing BMC Med Genomics Research BACKGROUND: Fat mass and obesity-related (FTO) mRNA was downregulated in osteonecrosis patients. The study aimed to evaluate the correlation between FTO polymorphisms and the susceptibility of osteonecrosis of the femoral head (ONFH). METHODS: Six polymorphisms in FTO were genotyped via the Agena MassARRAY in 498 ONFH patients and 498 healthy controls. Multiple genetic models were used to assess the correlation between FTO polymorphisms and ONFH risk by SNPStats. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a logistic regression model adjusted by age, gender, smoking and drinking. RESULTS: The risk-increasing association of rs62033406 A>G with ONFH was found (OR = 1.25, 95% CI 1.05–1.50, p = 0.014). Specially, FTO rs62033406 A>G was related to the risk of ONFH in the subgroup at age > 51 years (OR = 1.25, p = 4.00 × 10(–4)), females (OR = 1.74, p = 1.00 × 10(–4)), smokers (OR = 1.82, p = 0.005) and drinkers (OR = 1.89, p = 0.002), respectively. The best multi–loci model was the five–loci model, a combination of rs9930333 T>G, rs1558902 T>A, rs56094641 A>G, rs3751812 G>T, and rs62033406 A>G (testing accuracy, 0.5351; p = 0.0004; cross–validation consistency, 10/10). CONCLUSION: Our study first revealed that FTO rs62033406 A>G was a risk factor for ONFH among the Chinese Han population, which might provide the new candidate gene for elucidating the pathogenesis of ONFH. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01283-z. BioMed Central 2022-06-15 /pmc/articles/PMC9202150/ /pubmed/35706030 http://dx.doi.org/10.1186/s12920-022-01283-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wang, Yuan Zhong, Wei Wang, Shaofeng Yang, Yang Zhu, Bing FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population |
title | FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population |
title_full | FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population |
title_fullStr | FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population |
title_full_unstemmed | FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population |
title_short | FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population |
title_sort | fto rs62033406 a>g associated with the risk of osteonecrosis of the femoral head among the chinese han population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202150/ https://www.ncbi.nlm.nih.gov/pubmed/35706030 http://dx.doi.org/10.1186/s12920-022-01283-z |
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