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Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation

BACKGROUND: DNA methylation is involved in the epigenetic regulation of gene expression during developmental processes and is primarily established by the DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B). DNMT3A is one of the most frequently mutated genes in clonal hematopoiesis and leukemia, indic...

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Detalles Bibliográficos
Autores principales:	Cypris, Olivia, Franzen, Julia, Frobel, Joana, Glück, Philipp, Kuo, Chao-Chung, Schmitz, Stephani, Nüchtern, Selina, Zenke, Martin, Wagner, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202186/ https://www.ncbi.nlm.nih.gov/pubmed/35705990 http://dx.doi.org/10.1186/s12915-022-01343-x

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