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Micronized Dietary Okara Fiber: Characterization, Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus
[Image: see text] Diabetes mellitus (DM) is a lifelong devastating and debilitating disease with serious chronic complications. Okara is a byproduct generated from soymilk or tofu production and it has been reported to have antioxidant and lipid-lowering effects. However, the antidiabetic effects an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202274/ https://www.ncbi.nlm.nih.gov/pubmed/35722005 http://dx.doi.org/10.1021/acsomega.2c01541 |
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author | Huang, Yanping Ashaolu, Tolulope Joshua Olatunji, Opeyemi Joshua |
author_facet | Huang, Yanping Ashaolu, Tolulope Joshua Olatunji, Opeyemi Joshua |
author_sort | Huang, Yanping |
collection | PubMed |
description | [Image: see text] Diabetes mellitus (DM) is a lifelong devastating and debilitating disease with serious chronic complications. Okara is a byproduct generated from soymilk or tofu production and it has been reported to have antioxidant and lipid-lowering effects. However, the antidiabetic effects and pancreatic β-cells’ secretory functions of micronized okara fiber (MOF) have not been reported. Therefore, this study explored the antidiabetic effects and modulatory potentials of MOF on pancreatic β-cells’ secretory functions in a high fat/high sugar/streptozotocin rat model of diabetes mellitus. Fiber-rich okara was prepared by removing fat and proteins from freshly obtained okara, followed by micronization. Fiber-rich okara was prepared, micronized, and characterized for hydrophobicity, thermal stability, structure–function relationship, and antioxidant potentials. We then established a rat model of DM and MOF and two doses (100 and 400 mg kg(–1)) were administered to see its anti-DM effect. Four weeks of MOF supplementation significantly reduced blood glucose, increased serum insulin level, improved hepatorenal functions, glucose tolerance, and regenerated pancreatic β-cells in the treated DM rats. Furthermore, MOF significantly improved the pancreatic antioxidant defense system by significantly elevating glutathione peroxidase, catalase, and superoxide dismutase activities while depleting the malonaldehyde level in the pancreas of the treated diabetic rats. Our results indicated that MOF ameliorated DM by impeding hyperglycemia, hyperlipidemia, and oxidative stress and enhancing the secretory functions of the beta cells, suggesting that MOF might be used as a protective nutrient in DM. |
format | Online Article Text |
id | pubmed-9202274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-92022742022-06-17 Micronized Dietary Okara Fiber: Characterization, Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus Huang, Yanping Ashaolu, Tolulope Joshua Olatunji, Opeyemi Joshua ACS Omega [Image: see text] Diabetes mellitus (DM) is a lifelong devastating and debilitating disease with serious chronic complications. Okara is a byproduct generated from soymilk or tofu production and it has been reported to have antioxidant and lipid-lowering effects. However, the antidiabetic effects and pancreatic β-cells’ secretory functions of micronized okara fiber (MOF) have not been reported. Therefore, this study explored the antidiabetic effects and modulatory potentials of MOF on pancreatic β-cells’ secretory functions in a high fat/high sugar/streptozotocin rat model of diabetes mellitus. Fiber-rich okara was prepared by removing fat and proteins from freshly obtained okara, followed by micronization. Fiber-rich okara was prepared, micronized, and characterized for hydrophobicity, thermal stability, structure–function relationship, and antioxidant potentials. We then established a rat model of DM and MOF and two doses (100 and 400 mg kg(–1)) were administered to see its anti-DM effect. Four weeks of MOF supplementation significantly reduced blood glucose, increased serum insulin level, improved hepatorenal functions, glucose tolerance, and regenerated pancreatic β-cells in the treated DM rats. Furthermore, MOF significantly improved the pancreatic antioxidant defense system by significantly elevating glutathione peroxidase, catalase, and superoxide dismutase activities while depleting the malonaldehyde level in the pancreas of the treated diabetic rats. Our results indicated that MOF ameliorated DM by impeding hyperglycemia, hyperlipidemia, and oxidative stress and enhancing the secretory functions of the beta cells, suggesting that MOF might be used as a protective nutrient in DM. American Chemical Society 2022-05-31 /pmc/articles/PMC9202274/ /pubmed/35722005 http://dx.doi.org/10.1021/acsomega.2c01541 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Huang, Yanping Ashaolu, Tolulope Joshua Olatunji, Opeyemi Joshua Micronized Dietary Okara Fiber: Characterization, Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus |
title | Micronized Dietary Okara Fiber: Characterization,
Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective
Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus |
title_full | Micronized Dietary Okara Fiber: Characterization,
Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective
Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus |
title_fullStr | Micronized Dietary Okara Fiber: Characterization,
Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective
Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus |
title_full_unstemmed | Micronized Dietary Okara Fiber: Characterization,
Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective
Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus |
title_short | Micronized Dietary Okara Fiber: Characterization,
Antioxidant, Antihyperglycemic, Antihyperlipidemic, and Pancreato-Protective
Effects in High Fat Diet/Streptozotocin-Induced Diabetes Mellitus |
title_sort | micronized dietary okara fiber: characterization,
antioxidant, antihyperglycemic, antihyperlipidemic, and pancreato-protective
effects in high fat diet/streptozotocin-induced diabetes mellitus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202274/ https://www.ncbi.nlm.nih.gov/pubmed/35722005 http://dx.doi.org/10.1021/acsomega.2c01541 |
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