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Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are d...

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Detalles Bibliográficos
Autores principales:	Zhu, Xiaolei, Hollinger, Kristen R., Huang, Yiyao, Borjabad, Alejandra, Kim, Boe-Hyun, Arab, Tanina, Thomas, Ajit G., Moniruzzaman, Mohammed, Lovell, Lyndah, Turchinovich, Andrey, Witwer, Kenneth W., Volsky, David J., Haughey, Norman J., Slusher, Barbara S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202342/ https://www.ncbi.nlm.nih.gov/pubmed/35462006 http://dx.doi.org/10.1016/j.nbd.2022.105734

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