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Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso

The severe acute respiratory syndrome due to the new coronavirus (SARS-CoV-2), responsible for coronavirus disease (COVID-19), has severely tested the global health response capacity, with predictions of a fatality for developing countries. To evaluate the prevalence of anti-SARS-CoV- 2 antibodies i...

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Autores principales: Sagna, Tani, Ouedraogo, Paul, Traore, Lassina, Obiri-Yeboah, Dorcas, Yonli, Albert, Tapsoba, Aristide, Tovo, Frida, Sorgho, Abel, Zongo, Laetitia, Nikiema, Ouégo, Ilboudo, Dénise, Belemgnegre, Marius, Nadembega, Christelle W., Ouermi, Djeneba, Djigma, Florencia W., Zohoncon, Théodora M., Poaty, Henriette, Colizzi, Vittorio, Simpore, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202456/
https://www.ncbi.nlm.nih.gov/pubmed/35720802
http://dx.doi.org/10.4081/jphia.2022.1778
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author Sagna, Tani
Ouedraogo, Paul
Traore, Lassina
Obiri-Yeboah, Dorcas
Yonli, Albert
Tapsoba, Aristide
Tovo, Frida
Sorgho, Abel
Zongo, Laetitia
Nikiema, Ouégo
Ilboudo, Dénise
Belemgnegre, Marius
Nadembega, Christelle W.
Ouermi, Djeneba
Djigma, Florencia W.
Zohoncon, Théodora M.
Poaty, Henriette
Colizzi, Vittorio
Simpore, Jacques
author_facet Sagna, Tani
Ouedraogo, Paul
Traore, Lassina
Obiri-Yeboah, Dorcas
Yonli, Albert
Tapsoba, Aristide
Tovo, Frida
Sorgho, Abel
Zongo, Laetitia
Nikiema, Ouégo
Ilboudo, Dénise
Belemgnegre, Marius
Nadembega, Christelle W.
Ouermi, Djeneba
Djigma, Florencia W.
Zohoncon, Théodora M.
Poaty, Henriette
Colizzi, Vittorio
Simpore, Jacques
author_sort Sagna, Tani
collection PubMed
description The severe acute respiratory syndrome due to the new coronavirus (SARS-CoV-2), responsible for coronavirus disease (COVID-19), has severely tested the global health response capacity, with predictions of a fatality for developing countries. To evaluate the prevalence of anti-SARS-CoV- 2 antibodies in People Living with HIV (PLHIV) with no COVID-19 symptoms in Burkina Faso. Seroprevalence was estimated by performing a qualitative screening test for SARS-CoV-2-specific immunoglobulins. The STANDARD(TM) Q COVID-19 IgM/IgG Combo Test kit from SD BIOSENSOR was used. Parameters like HIV plasma viral load, CD4 T cell count and C-Reactive Protein (CRP) expression were estimated. This study enrolled a total of 200 PLHIV aged 4-87 years who are asymptomatic for COVID-19. There were 36 (18%) positive for SARS-CoV-2 IgM and/or IgG of which three (1.50%) were positive for SARS-CoV-2 IgM and 33 (16.50%) for IgG. Among participants diagnosed as IgM positive, 66.67% (2/3) had the highest HIV viral loads with the lowest CD4 T cell counts (p<0.0001). The expression of CRP was relatively higher in COVID-19 IgG positive individuals (7.95±12.5 mg/L) than negative individuals (6.26±6.92 mg/L; p=0.37). The rate of IgG and IgM SARS-CoV-2 immunoglobulin carriage (18%), accompanied by a relatively high CRP levels, was revealed in this study among PLHIV. This serologic evidence and mild inflammation suggest that Burkina Faso escaped the worst, not necessarily because there were not many SARS-CoV-2 infections in its population, but because factors including genetic and environmental, might have resulted in many asymptomatic carriers.
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spelling pubmed-92024562022-06-17 Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso Sagna, Tani Ouedraogo, Paul Traore, Lassina Obiri-Yeboah, Dorcas Yonli, Albert Tapsoba, Aristide Tovo, Frida Sorgho, Abel Zongo, Laetitia Nikiema, Ouégo Ilboudo, Dénise Belemgnegre, Marius Nadembega, Christelle W. Ouermi, Djeneba Djigma, Florencia W. Zohoncon, Théodora M. Poaty, Henriette Colizzi, Vittorio Simpore, Jacques J Public Health Afr Article The severe acute respiratory syndrome due to the new coronavirus (SARS-CoV-2), responsible for coronavirus disease (COVID-19), has severely tested the global health response capacity, with predictions of a fatality for developing countries. To evaluate the prevalence of anti-SARS-CoV- 2 antibodies in People Living with HIV (PLHIV) with no COVID-19 symptoms in Burkina Faso. Seroprevalence was estimated by performing a qualitative screening test for SARS-CoV-2-specific immunoglobulins. The STANDARD(TM) Q COVID-19 IgM/IgG Combo Test kit from SD BIOSENSOR was used. Parameters like HIV plasma viral load, CD4 T cell count and C-Reactive Protein (CRP) expression were estimated. This study enrolled a total of 200 PLHIV aged 4-87 years who are asymptomatic for COVID-19. There were 36 (18%) positive for SARS-CoV-2 IgM and/or IgG of which three (1.50%) were positive for SARS-CoV-2 IgM and 33 (16.50%) for IgG. Among participants diagnosed as IgM positive, 66.67% (2/3) had the highest HIV viral loads with the lowest CD4 T cell counts (p<0.0001). The expression of CRP was relatively higher in COVID-19 IgG positive individuals (7.95±12.5 mg/L) than negative individuals (6.26±6.92 mg/L; p=0.37). The rate of IgG and IgM SARS-CoV-2 immunoglobulin carriage (18%), accompanied by a relatively high CRP levels, was revealed in this study among PLHIV. This serologic evidence and mild inflammation suggest that Burkina Faso escaped the worst, not necessarily because there were not many SARS-CoV-2 infections in its population, but because factors including genetic and environmental, might have resulted in many asymptomatic carriers. PAGEPress Publications, Pavia, Italy 2022-05-25 /pmc/articles/PMC9202456/ /pubmed/35720802 http://dx.doi.org/10.4081/jphia.2022.1778 Text en ©Copyright: the Author(s) https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0).
spellingShingle Article
Sagna, Tani
Ouedraogo, Paul
Traore, Lassina
Obiri-Yeboah, Dorcas
Yonli, Albert
Tapsoba, Aristide
Tovo, Frida
Sorgho, Abel
Zongo, Laetitia
Nikiema, Ouégo
Ilboudo, Dénise
Belemgnegre, Marius
Nadembega, Christelle W.
Ouermi, Djeneba
Djigma, Florencia W.
Zohoncon, Théodora M.
Poaty, Henriette
Colizzi, Vittorio
Simpore, Jacques
Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso
title Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso
title_full Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso
title_fullStr Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso
title_full_unstemmed Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso
title_short Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso
title_sort enigma of the high prevalence of anti-sars-cov-2 antibodies in hiv-positive people with no symptoms of covid-19 in burkina faso
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202456/
https://www.ncbi.nlm.nih.gov/pubmed/35720802
http://dx.doi.org/10.4081/jphia.2022.1778
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