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Metal content and kinetic properties of yeast RNA lariat debranching enzyme Dbr1

In eukaryotic cells, intron lariats produced by the spliceosome contain a 2′5′ phosphodiester linkage. The RNA lariat debranching enzyme, Dbr1, is the only enzyme known to hydrolyze this bond. Dbr1 is a member of the metallophosphoesterase (MPE) family of enzymes, and recent X-ray crystal structures...

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Detalles Bibliográficos
Autores principales:	Clark, Nathaniel E., Katolik, Adam, Taggart, Allison J., Buerer, Luke, Holloway, Stephen P., Miller, Nathaniel, Phillips, John D., Farrell, Colin P., Damha, Masad J., Fairbrother, William G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202583/ https://www.ncbi.nlm.nih.gov/pubmed/35459748 http://dx.doi.org/10.1261/rna.079159.122

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