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Conformational heterogeneity of UCAAUC RNA oligonucleotide from molecular dynamics simulations, SAXS, and NMR experiments

We describe the conformational ensemble of the single-stranded r(UCAAUC) oligonucleotide obtained using extensive molecular dynamics (MD) simulations and Rosetta's FARFAR2 algorithm. The conformations observed in MD consist of A-form-like structures and variations thereof. These structures are...

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Detalles Bibliográficos
Autores principales:	Bergonzo, Christina, Grishaev, Alexander, Bottaro, Sandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202585/ https://www.ncbi.nlm.nih.gov/pubmed/35483823 http://dx.doi.org/10.1261/rna.078888.121

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