Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical use has been hampered by pleiotropic functionality and widespread receptor expression, with unexpected adverse events. Here, we developed a novel mouse st...

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Detalles Bibliográficos
Autores principales: Whyte, Carly E., Singh, Kailash, Burton, Oliver T., Aloulou, Meryem, Kouser, Lubna, Veiga, Rafael Valente, Dashwood, Amy, Okkenhaug, Hanneke, Benadda, Samira, Moudra, Alena, Bricard, Orian, Lienart, Stephanie, Bielefeld, Pascal, Roca, Carlos P., Naranjo-Galindo, Francisco José, Lombard-Vadnais, Félix, Junius, Steffie, Bending, David, Ono, Masahiro, Hochepied, Tino, Halim, Timotheus Y.F., Schlenner, Susan, Lesage, Sylvie, Dooley, James, Liston, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202720/
https://www.ncbi.nlm.nih.gov/pubmed/35699942
http://dx.doi.org/10.1084/jem.20212391

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