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Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors

BACKGROUND: Prenatal exposure to individual per- and poly-fluoroalkyl substances (PFAS) and psychosocial stressors have been associated with reductions in fetal growth. Studies suggest cumulative or joint effects of chemical and non-chemical stressors on fetal growth. However, few studies have exami...

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Autores principales: Eick, Stephanie M., Enright, Elizabeth A., Padula, Amy M., Aung, Max, Geiger, Sarah D., Cushing, Lara, Trowbridge, Jessica, Keil, Alexander P., Baek, Hyoung Gee, Smith, Sabrina, Park, June-Soo, DeMicco, Erin, Schantz, Susan L., Woodruff, Tracey J., Morello-Frosch, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202828/
https://www.ncbi.nlm.nih.gov/pubmed/35436721
http://dx.doi.org/10.1016/j.envint.2022.107238
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author Eick, Stephanie M.
Enright, Elizabeth A.
Padula, Amy M.
Aung, Max
Geiger, Sarah D.
Cushing, Lara
Trowbridge, Jessica
Keil, Alexander P.
Baek, Hyoung Gee
Smith, Sabrina
Park, June-Soo
DeMicco, Erin
Schantz, Susan L.
Woodruff, Tracey J.
Morello-Frosch, Rachel
author_facet Eick, Stephanie M.
Enright, Elizabeth A.
Padula, Amy M.
Aung, Max
Geiger, Sarah D.
Cushing, Lara
Trowbridge, Jessica
Keil, Alexander P.
Baek, Hyoung Gee
Smith, Sabrina
Park, June-Soo
DeMicco, Erin
Schantz, Susan L.
Woodruff, Tracey J.
Morello-Frosch, Rachel
author_sort Eick, Stephanie M.
collection PubMed
description BACKGROUND: Prenatal exposure to individual per- and poly-fluoroalkyl substances (PFAS) and psychosocial stressors have been associated with reductions in fetal growth. Studies suggest cumulative or joint effects of chemical and non-chemical stressors on fetal growth. However, few studies have examined PFAS and non-chemical stressors together as a mixture, which better reflects real life exposure patterns. We examined joint associations between PFAS, perceived stress, and depression, and fetal growth using two approaches developed for exposure mixtures. METHODS: Pregnant participants were enrolled in the Chemicals in Our Bodies cohort and Illinois Kids Development Study, which together make up the ECHO.CA.IL cohort. Seven PFAS were previously measured in 2nd trimester maternal serum samples and were natural log transformed for analyses. Perceived stress and depression were assessed using self-reported validated questionnaires, which were converted to t-scores using validated methods. Quantile g-computation and Bayesian kernel machine regression (BKMR) were used to assess joint associations between PFAS, perceived stress and depression t-scores and birthweight z-scores (N = 876). RESULTS: Individual PFAS, depression and perceived stress t-scores were negatively correlated with birthweight z-scores. Using quantile g-computation, a simultaneous one quartile increase in all PFAS, perceived stress and depression t-scores was associated with a slight reduction in birthweight z-scores (mean change per quartile increase = −0.09, 95% confidence interval = −0.21, 0.03). BKMR similarly indicated that cumulative PFAS and stress t-scores were modestly associated with lower birthweight z-scores. Across both methods, the joint association appeared to be distributed across multiple exposures rather than due to a single exposure. CONCLUSIONS: Our study is one of the first to examine the joint effects of chemical and non-chemical stressors on fetal growth using mixture methods. We found that PFAS, perceived stress, and depression in combination were modestly associated were lower birthweight z-scores, which supports prior studies indicating that chemical and non-chemical stressors are jointly associated with adverse health outcomes.
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spelling pubmed-92028282022-06-16 Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors Eick, Stephanie M. Enright, Elizabeth A. Padula, Amy M. Aung, Max Geiger, Sarah D. Cushing, Lara Trowbridge, Jessica Keil, Alexander P. Baek, Hyoung Gee Smith, Sabrina Park, June-Soo DeMicco, Erin Schantz, Susan L. Woodruff, Tracey J. Morello-Frosch, Rachel Environ Int Article BACKGROUND: Prenatal exposure to individual per- and poly-fluoroalkyl substances (PFAS) and psychosocial stressors have been associated with reductions in fetal growth. Studies suggest cumulative or joint effects of chemical and non-chemical stressors on fetal growth. However, few studies have examined PFAS and non-chemical stressors together as a mixture, which better reflects real life exposure patterns. We examined joint associations between PFAS, perceived stress, and depression, and fetal growth using two approaches developed for exposure mixtures. METHODS: Pregnant participants were enrolled in the Chemicals in Our Bodies cohort and Illinois Kids Development Study, which together make up the ECHO.CA.IL cohort. Seven PFAS were previously measured in 2nd trimester maternal serum samples and were natural log transformed for analyses. Perceived stress and depression were assessed using self-reported validated questionnaires, which were converted to t-scores using validated methods. Quantile g-computation and Bayesian kernel machine regression (BKMR) were used to assess joint associations between PFAS, perceived stress and depression t-scores and birthweight z-scores (N = 876). RESULTS: Individual PFAS, depression and perceived stress t-scores were negatively correlated with birthweight z-scores. Using quantile g-computation, a simultaneous one quartile increase in all PFAS, perceived stress and depression t-scores was associated with a slight reduction in birthweight z-scores (mean change per quartile increase = −0.09, 95% confidence interval = −0.21, 0.03). BKMR similarly indicated that cumulative PFAS and stress t-scores were modestly associated with lower birthweight z-scores. Across both methods, the joint association appeared to be distributed across multiple exposures rather than due to a single exposure. CONCLUSIONS: Our study is one of the first to examine the joint effects of chemical and non-chemical stressors on fetal growth using mixture methods. We found that PFAS, perceived stress, and depression in combination were modestly associated were lower birthweight z-scores, which supports prior studies indicating that chemical and non-chemical stressors are jointly associated with adverse health outcomes. 2022-05 2022-04-09 /pmc/articles/PMC9202828/ /pubmed/35436721 http://dx.doi.org/10.1016/j.envint.2022.107238 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Eick, Stephanie M.
Enright, Elizabeth A.
Padula, Amy M.
Aung, Max
Geiger, Sarah D.
Cushing, Lara
Trowbridge, Jessica
Keil, Alexander P.
Baek, Hyoung Gee
Smith, Sabrina
Park, June-Soo
DeMicco, Erin
Schantz, Susan L.
Woodruff, Tracey J.
Morello-Frosch, Rachel
Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors
title Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors
title_full Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors
title_fullStr Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors
title_full_unstemmed Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors
title_short Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors
title_sort prenatal pfas and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: applying environmental mixture methods to chemical and non-chemical stressors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202828/
https://www.ncbi.nlm.nih.gov/pubmed/35436721
http://dx.doi.org/10.1016/j.envint.2022.107238
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