Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies

A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods. Compound 40 (MIC~ 8 μM) was the most potent among all 60 compounds,...

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Detalles Bibliográficos
Autores principales: Lagu, Surendra Babu, Yejella, Rajendra Prasad, Nissankararao, Srinath, Bhandare, Richie R., Golla, Venu Sampath, Subrahmanya Lokesh, Bontha Venkata, Rahman, M. Mukhlesur, Shaik, Afzal Basha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202851/
https://www.ncbi.nlm.nih.gov/pubmed/35709194
http://dx.doi.org/10.1371/journal.pone.0265068

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