Cargando…

Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model

The classical SEIR model, being an autonomous system of differential equations, has important limitations when representing a pandemic situation. Particularly, the geometric unimodal shape of the epidemic curve is not what is generally observed. This work introduces the βSEIR model, which adds to th...

Descripción completa

Detalles Bibliográficos
Autores principales: Córdova-Lepe, Fernando, Vogt-Geisse, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202926/
https://www.ncbi.nlm.nih.gov/pubmed/35709241
http://dx.doi.org/10.1371/journal.pone.0269843
_version_ 1784728618479386624
author Córdova-Lepe, Fernando
Vogt-Geisse, Katia
author_facet Córdova-Lepe, Fernando
Vogt-Geisse, Katia
author_sort Córdova-Lepe, Fernando
collection PubMed
description The classical SEIR model, being an autonomous system of differential equations, has important limitations when representing a pandemic situation. Particularly, the geometric unimodal shape of the epidemic curve is not what is generally observed. This work introduces the βSEIR model, which adds to the classical SEIR model a differential law to model the variation in the transmission rate. It considers two opposite thrives generally found in a population: first, reaction to disease presence that may be linked to mitigation strategies, which tends to decrease transmission, and second, the urge to return to normal conditions that pulls to restore the initial value of the transmission rate. Our results open a wide spectrum of dynamic variabilities in the curve of new infected, which are justified by reaction and restoration thrives that affect disease transmission over time. Some of these dynamics have been observed in the existing COVID-19 disease data. In particular and to further exemplify the potential of the model proposed in this article, we show its capability of capturing the evolution of the number of new confirmed cases of Chile and Italy for several months after epidemic onset, while incorporating a reaction to disease presence with decreasing adherence to mitigation strategies, as well as a seasonal effect on the restoration of the initial transmissibility conditions.
format Online
Article
Text
id pubmed-9202926
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-92029262022-06-17 Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model Córdova-Lepe, Fernando Vogt-Geisse, Katia PLoS One Research Article The classical SEIR model, being an autonomous system of differential equations, has important limitations when representing a pandemic situation. Particularly, the geometric unimodal shape of the epidemic curve is not what is generally observed. This work introduces the βSEIR model, which adds to the classical SEIR model a differential law to model the variation in the transmission rate. It considers two opposite thrives generally found in a population: first, reaction to disease presence that may be linked to mitigation strategies, which tends to decrease transmission, and second, the urge to return to normal conditions that pulls to restore the initial value of the transmission rate. Our results open a wide spectrum of dynamic variabilities in the curve of new infected, which are justified by reaction and restoration thrives that affect disease transmission over time. Some of these dynamics have been observed in the existing COVID-19 disease data. In particular and to further exemplify the potential of the model proposed in this article, we show its capability of capturing the evolution of the number of new confirmed cases of Chile and Italy for several months after epidemic onset, while incorporating a reaction to disease presence with decreasing adherence to mitigation strategies, as well as a seasonal effect on the restoration of the initial transmissibility conditions. Public Library of Science 2022-06-16 /pmc/articles/PMC9202926/ /pubmed/35709241 http://dx.doi.org/10.1371/journal.pone.0269843 Text en © 2022 Córdova-Lepe, Vogt-Geisse https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Córdova-Lepe, Fernando
Vogt-Geisse, Katia
Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model
title Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model
title_full Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model
title_fullStr Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model
title_full_unstemmed Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model
title_short Adding a reaction-restoration type transmission rate dynamic-law to the basic SEIR COVID-19 model
title_sort adding a reaction-restoration type transmission rate dynamic-law to the basic seir covid-19 model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202926/
https://www.ncbi.nlm.nih.gov/pubmed/35709241
http://dx.doi.org/10.1371/journal.pone.0269843
work_keys_str_mv AT cordovalepefernando addingareactionrestorationtypetransmissionratedynamiclawtothebasicseircovid19model
AT vogtgeissekatia addingareactionrestorationtypetransmissionratedynamiclawtothebasicseircovid19model