Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India

Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & Methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2...

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Detalles Bibliográficos
Autores principales: Rajpal, Vijay Rani, Sharma, Shashi, Kumar, Avinash, Vaishnavi, Samantha, Singh, Apekshita, Sehgal, Deepmala, Tiwari, Mughdha, Goel, Shailendra, Raina, Soom Nath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203035/
https://www.ncbi.nlm.nih.gov/pubmed/35747327
http://dx.doi.org/10.2217/fvl-2021-0267
Descripción
Sumario:Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & Methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021. Results: The study revealed 242 mutations corresponding to 207 sites. Fifty one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave). Conclusion: The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics.

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