Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India

Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & Methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2...

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Autores principales: Rajpal, Vijay Rani, Sharma, Shashi, Kumar, Avinash, Vaishnavi, Samantha, Singh, Apekshita, Sehgal, Deepmala, Tiwari, Mughdha, Goel, Shailendra, Raina, Soom Nath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203035/
https://www.ncbi.nlm.nih.gov/pubmed/35747327
http://dx.doi.org/10.2217/fvl-2021-0267
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author Rajpal, Vijay Rani
Sharma, Shashi
Kumar, Avinash
Vaishnavi, Samantha
Singh, Apekshita
Sehgal, Deepmala
Tiwari, Mughdha
Goel, Shailendra
Raina, Soom Nath
author_facet Rajpal, Vijay Rani
Sharma, Shashi
Kumar, Avinash
Vaishnavi, Samantha
Singh, Apekshita
Sehgal, Deepmala
Tiwari, Mughdha
Goel, Shailendra
Raina, Soom Nath
author_sort Rajpal, Vijay Rani
collection PubMed
description Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & Methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021. Results: The study revealed 242 mutations corresponding to 207 sites. Fifty one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave). Conclusion: The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics.
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spelling pubmed-92030352022-06-21 Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India Rajpal, Vijay Rani Sharma, Shashi Kumar, Avinash Vaishnavi, Samantha Singh, Apekshita Sehgal, Deepmala Tiwari, Mughdha Goel, Shailendra Raina, Soom Nath Future Virol Research Article Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & Methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021. Results: The study revealed 242 mutations corresponding to 207 sites. Fifty one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave). Conclusion: The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics. Future Medicine Ltd 2022-06-03 2022-05 /pmc/articles/PMC9203035/ /pubmed/35747327 http://dx.doi.org/10.2217/fvl-2021-0267 Text en © 2022 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Rajpal, Vijay Rani
Sharma, Shashi
Kumar, Avinash
Vaishnavi, Samantha
Singh, Apekshita
Sehgal, Deepmala
Tiwari, Mughdha
Goel, Shailendra
Raina, Soom Nath
Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India
title Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India
title_full Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India
title_fullStr Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India
title_full_unstemmed Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India
title_short Mapping of SARS-CoV-2 spike protein evolution during first and second waves of COVID-19 infections in India
title_sort mapping of sars-cov-2 spike protein evolution during first and second waves of covid-19 infections in india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203035/
https://www.ncbi.nlm.nih.gov/pubmed/35747327
http://dx.doi.org/10.2217/fvl-2021-0267
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