Cargando…
Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins
Two meters of DNA in each of our cells must be protected against many types of damage. Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of intermediate filament proteins, but very different patterns of expression and regulation between different cells and tissues re...
Autores principales: | Wang, Mai, Ivanovska, Irena, Vashisth, Manasvita, Discher, Dennis E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203124/ https://www.ncbi.nlm.nih.gov/pubmed/35719698 http://dx.doi.org/10.1063/5.0080392 |
Ejemplares similares
-
Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
por: Pfeifer, Charlotte R., et al.
Publicado: (2022) -
Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival
por: Harada, Takamasa, et al.
Publicado: (2014) -
Nuclear constriction segregates mobile nuclear proteins away from chromatin
por: Irianto, Jerome, et al.
Publicado: (2016) -
Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation
por: Ivanovska, Irena L., et al.
Publicado: (2017) -
Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes
por: Buxboim, Amnon, et al.
Publicado: (2017)