The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Mitochondrial metabolites regulate leukaemic and normal stem cells by affecting epigenetic marks. How mitochondrial enzymes localize to the nucleus to control stem cell function is less understood. We discovered that the mitochondrial metabolic enzyme hexokinase 2 (HK2) localizes to the nucleus in l...

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Detalles Bibliográficos
Autores principales: Thomas, Geethu Emily, Egan, Grace, García-Prat, Laura, Botham, Aaron, Voisin, Veronique, Patel, Parasvi S., Hoff, Fieke W., Chin, Jordan, Nachmias, Boaz, Kaufmann, Kerstin B., Khan, Dilshad H., Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, MacLean, Neil, O’Brien, Cristiana, Singh, Rashim P., Jones, Courtney L., Harding, Shane M., Raught, Brian, Arruda, Andrea, Minden, Mark D., Bader, Gary D., Hakem, Razq, Kornblau, Steve, Dick, John E., Schimmer, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203277/
https://www.ncbi.nlm.nih.gov/pubmed/35668135
http://dx.doi.org/10.1038/s41556-022-00925-9

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