Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this property, naive cells are thought to lack chromatin-based lineage barriers. However, this assumption has not been tested. Here we define the chromatin-associated proteome, histone post-translational modificatio...

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Detalles Bibliográficos
Autores principales: Zijlmans, Dick W., Talon, Irene, Verhelst, Sigrid, Bendall, Adam, Van Nerum, Karlien, Javali, Alok, Malcolm, Andrew A., van Knippenberg, Sam S. F. A., Biggins, Laura, To, San Kit, Janiszewski, Adrian, Admiraal, Danielle, Knops, Ruth, Corthout, Nikky, Balaton, Bradley P., Georgolopoulos, Grigorios, Panda, Amitesh, Bhanu, Natarajan V., Collier, Amanda J., Fabian, Charlene, Allsop, Ryan N., Chappell, Joel, Pham, Thi Xuan Ai, Oberhuemer, Michael, Ertekin, Cankat, Vanheer, Lotte, Athanasouli, Paraskevi, Lluis, Frederic, Deforce, Dieter, Jansen, Joop H., Garcia, Benjamin A., Vermeulen, Michiel, Rivron, Nicolas, Dhaenens, Maarten, Marks, Hendrik, Rugg-Gunn, Peter J., Pasque, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203278/
https://www.ncbi.nlm.nih.gov/pubmed/35697783
http://dx.doi.org/10.1038/s41556-022-00932-w

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