A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic mechanism that couples cell growth and survival to bioenergetic demands. Using conditional knockout ATF4 mice, we show that gl...

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Detalles Bibliográficos
Autores principales: Verginadis, Ioannis I., Avgousti, Harris, Monslow, James, Skoufos, Giorgos, Chinga, Frank, Kim, Kyle, Leli, Nektaria Maria, Karagounis, Ilias V., Bell, Brett I., Velalopoulou, Anastasia, Salinas, Carlo Salas, Wu, Victoria S., Li, Yang, Ye, Jiangbin, Scott, David A., Osterman, Andrei L., Sengupta, Arjun, Weljie, Aalim, Huang, Menggui, Zhang, Duo, Fan, Yi, Radaelli, Enrico, Tobias, John W., Rambow, Florian, Karras, Panagiotis, Marine, Jean-Christophe, Xu, Xiaowei, Hatzigeorgiou, Artemis G., Ryeom, Sandra, Diehl, J. Alan, Fuchs, Serge Y., Puré, Ellen, Koumenis, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203279/
https://www.ncbi.nlm.nih.gov/pubmed/35654839
http://dx.doi.org/10.1038/s41556-022-00918-8

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