Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical cellular diversity despite the tremendous upsurge in derivation methods, suggesting inadequate patterning of early neural stem cells (NSCs). Here we show that a short and early Dual SMAD and WNT inhibition course...

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Detalles Bibliográficos
Autores principales: Rosebrock, Daniel, Arora, Sneha, Mutukula, Naresh, Volkman, Rotem, Gralinska, Elzbieta, Balaskas, Anastasios, Aragonés Hernández, Amèlia, Buschow, René, Brändl, Björn, Müller, Franz-Josef, Arndt, Peter F., Vingron, Martin, Elkabetz, Yechiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203281/
https://www.ncbi.nlm.nih.gov/pubmed/35697781
http://dx.doi.org/10.1038/s41556-022-00929-5

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