microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting DNMT1

The incidence of post-operative cognitive dysfunction (POCD) remains a relatively prevalent complication in the elderly after surgery, especially in those receiving sevoflurane (Sevo) anesthesia. microRNA (miR)−140-3p has been demonstrated to orchestrate neuroinflammation and neuron apoptosis. Howev...

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Detalles Bibliográficos
Autores principales: Wu, Zhiguo, Tan, Jian, Lin, Lichang, Zhang, Wenting, Yuan, Wanqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203584/
https://www.ncbi.nlm.nih.gov/pubmed/35710537
http://dx.doi.org/10.1038/s41420-022-01068-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203584/
https://www.ncbi.nlm.nih.gov/pubmed/35710537
http://dx.doi.org/10.1038/s41420-022-01068-4

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