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Cryo-EM structure of the prothrombin-prothrombinase complex

The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca(2+) and phospholipids, activates the zymogen prothrombin to the protease thrombin. The reaction entails cleavage at...

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Detalles Bibliográficos
Autores principales:	Ruben, Eliza A., Summers, Brock, Rau, Michael J., Fitzpatrick, James A. J., Di Cera, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Plenary Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203702/ https://www.ncbi.nlm.nih.gov/pubmed/35427420 http://dx.doi.org/10.1182/blood.2022015807

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