Cargando…
The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203711/ https://www.ncbi.nlm.nih.gov/pubmed/35710924 http://dx.doi.org/10.1038/s41598-022-14177-y |
_version_ | 1784728756421656576 |
---|---|
author | Lindblom, Anna Kiszakiewicz, Camilla Kristiansson, Erik Yazdanshenas, Shora Kamenska, Nina Karami, Nahid Åhrén, Christina |
author_facet | Lindblom, Anna Kiszakiewicz, Camilla Kristiansson, Erik Yazdanshenas, Shora Kamenska, Nina Karami, Nahid Åhrén, Christina |
author_sort | Lindblom, Anna |
collection | PubMed |
description | The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode of UTI due to ESBL-E. coli. Our aim was to evaluate the impact of the globally dominant sequence type (ST)131 clone and its clades, on the risk of subsequent recurrences with ESBL-E. coli. Isolates from patients developing RUTI (68/297) were compared with those from patients with sporadic UTI (SUTI, 229/297). No association was found between RUTI and the two most prevalent phylogroups B2 and D, bla(CTX-M) genes, or resistance profile. Half of the patients with RUTI were infected with ST131 isolates. Clade C2 were in dominance (50/119) among ST131 isolates. They were more common in patients with RUTI than SUTI (28% vs 13%) and multivariate analysis showed an increased odds-ratio (OR = 2.21, p = 0.033) for recurrences in patients infected with these isolates as compared to non-ST131 isolates. Detecting specific biomarkers, as ST131 clade C2, in ESBL-E. coli UTI isolates may aid in prediction of RUTI and improve diagnostics and care of patients with a risk of ESBL-E. coli recurrences. |
format | Online Article Text |
id | pubmed-9203711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92037112022-06-18 The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study Lindblom, Anna Kiszakiewicz, Camilla Kristiansson, Erik Yazdanshenas, Shora Kamenska, Nina Karami, Nahid Åhrén, Christina Sci Rep Article The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode of UTI due to ESBL-E. coli. Our aim was to evaluate the impact of the globally dominant sequence type (ST)131 clone and its clades, on the risk of subsequent recurrences with ESBL-E. coli. Isolates from patients developing RUTI (68/297) were compared with those from patients with sporadic UTI (SUTI, 229/297). No association was found between RUTI and the two most prevalent phylogroups B2 and D, bla(CTX-M) genes, or resistance profile. Half of the patients with RUTI were infected with ST131 isolates. Clade C2 were in dominance (50/119) among ST131 isolates. They were more common in patients with RUTI than SUTI (28% vs 13%) and multivariate analysis showed an increased odds-ratio (OR = 2.21, p = 0.033) for recurrences in patients infected with these isolates as compared to non-ST131 isolates. Detecting specific biomarkers, as ST131 clade C2, in ESBL-E. coli UTI isolates may aid in prediction of RUTI and improve diagnostics and care of patients with a risk of ESBL-E. coli recurrences. Nature Publishing Group UK 2022-06-16 /pmc/articles/PMC9203711/ /pubmed/35710924 http://dx.doi.org/10.1038/s41598-022-14177-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lindblom, Anna Kiszakiewicz, Camilla Kristiansson, Erik Yazdanshenas, Shora Kamenska, Nina Karami, Nahid Åhrén, Christina The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study |
title | The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study |
title_full | The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study |
title_fullStr | The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study |
title_full_unstemmed | The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study |
title_short | The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study |
title_sort | impact of the st131 clone on recurrent esbl-producing e. coli urinary tract infection: a prospective comparative study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203711/ https://www.ncbi.nlm.nih.gov/pubmed/35710924 http://dx.doi.org/10.1038/s41598-022-14177-y |
work_keys_str_mv | AT lindblomanna theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT kiszakiewiczcamilla theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT kristianssonerik theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT yazdanshenasshora theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT kamenskanina theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT karaminahid theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT ahrenchristina theimpactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT lindblomanna impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT kiszakiewiczcamilla impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT kristianssonerik impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT yazdanshenasshora impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT kamenskanina impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT karaminahid impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy AT ahrenchristina impactofthest131cloneonrecurrentesblproducingecoliurinarytractinfectionaprospectivecomparativestudy |