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The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study

The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode...

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Autores principales: Lindblom, Anna, Kiszakiewicz, Camilla, Kristiansson, Erik, Yazdanshenas, Shora, Kamenska, Nina, Karami, Nahid, Åhrén, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203711/
https://www.ncbi.nlm.nih.gov/pubmed/35710924
http://dx.doi.org/10.1038/s41598-022-14177-y
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author Lindblom, Anna
Kiszakiewicz, Camilla
Kristiansson, Erik
Yazdanshenas, Shora
Kamenska, Nina
Karami, Nahid
Åhrén, Christina
author_facet Lindblom, Anna
Kiszakiewicz, Camilla
Kristiansson, Erik
Yazdanshenas, Shora
Kamenska, Nina
Karami, Nahid
Åhrén, Christina
author_sort Lindblom, Anna
collection PubMed
description The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode of UTI due to ESBL-E. coli. Our aim was to evaluate the impact of the globally dominant sequence type (ST)131 clone and its clades, on the risk of subsequent recurrences with ESBL-E. coli. Isolates from patients developing RUTI (68/297) were compared with those from patients with sporadic UTI (SUTI, 229/297). No association was found between RUTI and the two most prevalent phylogroups B2 and D, bla(CTX-M) genes, or resistance profile. Half of the patients with RUTI were infected with ST131 isolates. Clade C2 were in dominance (50/119) among ST131 isolates. They were more common in patients with RUTI than SUTI (28% vs 13%) and multivariate analysis showed an increased odds-ratio (OR = 2.21, p = 0.033) for recurrences in patients infected with these isolates as compared to non-ST131 isolates. Detecting specific biomarkers, as ST131 clade C2, in ESBL-E. coli UTI isolates may aid in prediction of RUTI and improve diagnostics and care of patients with a risk of ESBL-E. coli recurrences.
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spelling pubmed-92037112022-06-18 The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study Lindblom, Anna Kiszakiewicz, Camilla Kristiansson, Erik Yazdanshenas, Shora Kamenska, Nina Karami, Nahid Åhrén, Christina Sci Rep Article The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode of UTI due to ESBL-E. coli. Our aim was to evaluate the impact of the globally dominant sequence type (ST)131 clone and its clades, on the risk of subsequent recurrences with ESBL-E. coli. Isolates from patients developing RUTI (68/297) were compared with those from patients with sporadic UTI (SUTI, 229/297). No association was found between RUTI and the two most prevalent phylogroups B2 and D, bla(CTX-M) genes, or resistance profile. Half of the patients with RUTI were infected with ST131 isolates. Clade C2 were in dominance (50/119) among ST131 isolates. They were more common in patients with RUTI than SUTI (28% vs 13%) and multivariate analysis showed an increased odds-ratio (OR = 2.21, p = 0.033) for recurrences in patients infected with these isolates as compared to non-ST131 isolates. Detecting specific biomarkers, as ST131 clade C2, in ESBL-E. coli UTI isolates may aid in prediction of RUTI and improve diagnostics and care of patients with a risk of ESBL-E. coli recurrences. Nature Publishing Group UK 2022-06-16 /pmc/articles/PMC9203711/ /pubmed/35710924 http://dx.doi.org/10.1038/s41598-022-14177-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lindblom, Anna
Kiszakiewicz, Camilla
Kristiansson, Erik
Yazdanshenas, Shora
Kamenska, Nina
Karami, Nahid
Åhrén, Christina
The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
title The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
title_full The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
title_fullStr The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
title_full_unstemmed The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
title_short The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
title_sort impact of the st131 clone on recurrent esbl-producing e. coli urinary tract infection: a prospective comparative study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203711/
https://www.ncbi.nlm.nih.gov/pubmed/35710924
http://dx.doi.org/10.1038/s41598-022-14177-y
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