CRISPR/Cas9 editing of the MYO7A gene in rhesus macaque embryos to generate a primate model of Usher syndrome type 1B

Mutations in the MYO7A gene lead to Usher syndrome type 1B (USH1B), a disease characterized by congenital deafness, vision loss, and balance impairment. To create a nonhuman primate (NHP) USH1B model, CRISPR/Cas9 was used to disrupt MYO7A in rhesus macaque zygotes. The targeting efficiency of Cas9 m...

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Detalles Bibliográficos
Autores principales: Ryu, Junghyun, Statz, John P., Chan, William, Burch, Fernanda C., Brigande, John V., Kempton, Beth, Porsov, Edward V., Renner, Lauren, McGill, Trevor, Burwitz, Benjamin J., Hanna, Carol B., Neuringer, Martha, Hennebold, Jon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203743/
https://www.ncbi.nlm.nih.gov/pubmed/35710827
http://dx.doi.org/10.1038/s41598-022-13689-x

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