Cargando…

Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer’s disease experimental models

The most accepted hypothesis in Alzheimer’s disease (AD) is the amyloid cascade which establishes that Aβ accumulation may induce the disease development. This accumulation may occur years before the clinical symptoms but it has not been elucidated if this accumulation is the cause or the consequenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	de la Cueva, Macarena, Antequera, Desiree, Ordoñez-Gutierrez, Lara, Wandosell, Francisco, Camins, Antonio, Carro, Eva, Bartolome, Fernando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203760/ https://www.ncbi.nlm.nih.gov/pubmed/35710783 http://dx.doi.org/10.1038/s41598-022-13683-3

Ejemplares similares

Author Correction: Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer’s disease experimental models
por: de la Cueva, Macarena, et al.
Publicado: (2023)

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition
por: Bartolome, Fernando, et al.
Publicado: (2018)

Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
por: Bartolome, Fernando, et al.
Publicado: (2020)

Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina
por: Carrero, Laura, et al.
Publicado: (2023)

Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer’s disease
por: Bartolome, Fernando, et al.
Publicado: (2020)

Trehalose Reduces the Secreted Beta-Amyloid Levels in Primary Neurons Independently of Autophagy Induction
por: Benito-Cuesta, Irene, et al.
Publicado: (2021)

Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
por: Bartolome, Fernando, et al.
Publicado: (2017)

Salivary Lactoferrin Expression in a Mouse Model of Alzheimer’s Disease
por: Antequera, Desiree, et al.
Publicado: (2021)

Nanoliposomes as a Therapeutic Tool for Alzheimer’s Disease
por: Ordóñez-Gutiérrez, Lara, et al.
Publicado: (2020)

Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer’s Disease
por: Municio, Cristina, et al.
Publicado: (2023)

Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease
por: Blanco-Palmero, Víctor Antonio, et al.
Publicado: (2021)

Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice
por: Ordóñez-Gutiérrez, Lara, et al.
Publicado: (2021)

Assessment of Autophagy in Neurons and Brain Tissue
por: Benito-Cuesta, Irene, et al.
Publicado: (2017)

Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: a pilot study
por: Bermejo-Pareja, Felix, et al.
Publicado: (2010)

Standardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease
por: Bartolome, Fernando, et al.
Publicado: (2021)

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons
por: Ludtmann, Marthe H. R., et al.
Publicado: (2017)

Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer’s Disease
por: Antequera, Desiree, et al.
Publicado: (2022)

Intranasal Delivery of Plasma and Platelet Growth Factors Using PRGF-Endoret System Enhances Neurogenesis in a Mouse Model of Alzheimer’s Disease
por: Anitua, Eduardo, et al.
Publicado: (2013)

Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease
por: Carrero, Laura, et al.
Publicado: (2023)

Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin
por: Carro, Eva, et al.
Publicado: (2017)

Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research
por: Yuan, Minghao, et al.
Publicado: (2023)

Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium
por: Vargas, Teo, et al.
Publicado: (2010)

Salivary lactoferrin as biomarker for Alzheimer's disease: Brain‐immunity interactions
por: Bermejo‐Pareja, Félix, et al.
Publicado: (2020)

C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson’s Disease
por: Sierra-Magro, Ana, et al.
Publicado: (2023)

Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients
por: González-Sánchez, Marta, et al.
Publicado: (2020)

Decreased salivary lactoferrin levels are specific to Alzheimer's disease
por: González-Sánchez, Marta, et al.
Publicado: (2020)

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
por: Anandatheerthavarada, Hindupur K., et al.
Publicado: (2003)

Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer’s disease experimental models
por: Kim, Joonki, et al.
Publicado: (2013)

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates
por: Bartolome, Fernando, et al.
Publicado: (2017)

Oxidative Stress in Tauopathies: From Cause to Therapy
por: Bartolome, Fernando, et al.
Publicado: (2022)

Soluble Megalin is Reduced in Cerebrospinal Fluid Samples of Alzheimer’s Disease Patients
por: Spuch, Carlos, et al.
Publicado: (2015)

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates
por: Bartolome, Fernando, et al.
Publicado: (2018)

Evidence for impaired amyloid β clearance in Alzheimer's disease
por: Wildsmith, Kristin R, et al.
Publicado: (2013)

Impaired hepatic amyloid-beta degradation in Alzheimer’s disease
por: Maarouf, Chera L., et al.
Publicado: (2018)

Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer’s Disease Patients
por: Bartolomé, Fernando, et al.
Publicado: (2022)

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
por: Griñán-Ferré, Christian, et al.
Publicado: (2016)

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
por: Chen, Shi-Yu, et al.
Publicado: (2020)

Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function
por: Ali, Syed Aoun, et al.
Publicado: (2023)

Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet–Mediated Amyloid Aggregation in Alzheimer’s Disease
por: Donner, Lili, et al.
Publicado: (2021)

Using Drosophila Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer's Disease
por: O'Keefe, Louise, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_de3qnim0pk0i9bibk9e9umod6r