Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis

The long non-coding RNA HOTAIR is the most differentially expressed gene between upper- and lower-body adipose tissue, yet its functional significance in adipogenesis is unclear. We report that HOTAIR expression is transiently induced during early adipogenic differentiation of gluteofemoral adipose...

Descripción completa

Detalles Bibliográficos
Autores principales: Potolitsyna, Evdokiia, Hazell Pickering, Sarah, Germier, Thomas, Collas, Philippe, Briand, Nolwenn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203762/
https://www.ncbi.nlm.nih.gov/pubmed/35710716
http://dx.doi.org/10.1038/s41598-022-14296-6
_version_ 1784728769561362432
author Potolitsyna, Evdokiia
Hazell Pickering, Sarah
Germier, Thomas
Collas, Philippe
Briand, Nolwenn
author_facet Potolitsyna, Evdokiia
Hazell Pickering, Sarah
Germier, Thomas
Collas, Philippe
Briand, Nolwenn
author_sort Potolitsyna, Evdokiia
collection PubMed
description The long non-coding RNA HOTAIR is the most differentially expressed gene between upper- and lower-body adipose tissue, yet its functional significance in adipogenesis is unclear. We report that HOTAIR expression is transiently induced during early adipogenic differentiation of gluteofemoral adipose progenitors and repressed in mature adipocytes. Upon adipogenic commitment, HOTAIR regulates protein synthesis pathways and cytoskeleton remodeling with a later impact on mature adipocyte lipid storage capacity. Our results support novel and important functions of HOTAIR in the physiological context of adipogenesis.
format Online
Article
Text
id pubmed-9203762
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92037622022-06-18 Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis Potolitsyna, Evdokiia Hazell Pickering, Sarah Germier, Thomas Collas, Philippe Briand, Nolwenn Sci Rep Article The long non-coding RNA HOTAIR is the most differentially expressed gene between upper- and lower-body adipose tissue, yet its functional significance in adipogenesis is unclear. We report that HOTAIR expression is transiently induced during early adipogenic differentiation of gluteofemoral adipose progenitors and repressed in mature adipocytes. Upon adipogenic commitment, HOTAIR regulates protein synthesis pathways and cytoskeleton remodeling with a later impact on mature adipocyte lipid storage capacity. Our results support novel and important functions of HOTAIR in the physiological context of adipogenesis. Nature Publishing Group UK 2022-06-16 /pmc/articles/PMC9203762/ /pubmed/35710716 http://dx.doi.org/10.1038/s41598-022-14296-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Potolitsyna, Evdokiia
Hazell Pickering, Sarah
Germier, Thomas
Collas, Philippe
Briand, Nolwenn
Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
title Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
title_full Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
title_fullStr Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
title_full_unstemmed Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
title_short Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
title_sort long non-coding rna hotair regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203762/
https://www.ncbi.nlm.nih.gov/pubmed/35710716
http://dx.doi.org/10.1038/s41598-022-14296-6
work_keys_str_mv AT potolitsynaevdokiia longnoncodingrnahotairregulatescytoskeletonremodelingandlipidstoragecapacityduringadipogenesis
AT hazellpickeringsarah longnoncodingrnahotairregulatescytoskeletonremodelingandlipidstoragecapacityduringadipogenesis
AT germierthomas longnoncodingrnahotairregulatescytoskeletonremodelingandlipidstoragecapacityduringadipogenesis
AT collasphilippe longnoncodingrnahotairregulatescytoskeletonremodelingandlipidstoragecapacityduringadipogenesis
AT briandnolwenn longnoncodingrnahotairregulatescytoskeletonremodelingandlipidstoragecapacityduringadipogenesis

Ejemplares similares