Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecula...

Descripción completa

Detalles Bibliográficos
Autores principales: Nefzger, Christian M., Jardé, Thierry, Srivastava, Akanksha, Schroeder, Jan, Rossello, Fernando J., Horvay, Katja, Prasko, Mirsada, Paynter, Jacob M., Chen, Joseph, Weng, Chen-Fang, Sun, Yu B. Y., Liu, Xiaodong, Chan, Eva, Deshpande, Nikita, Chen, Xiaoli, Li, Y. Jinhua, Pflueger, Jahnvi, Engel, Rebekah M., Knaupp, Anja S., Tsyganov, Kirill, Nilsson, Susan K., Lister, Ryan, Rackham, Owen J. L., Abud, Helen E., Polo, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203768/
https://www.ncbi.nlm.nih.gov/pubmed/35710627
http://dx.doi.org/10.1038/s41536-022-00226-7
_version_ 1784728771652222976
author Nefzger, Christian M.
Jardé, Thierry
Srivastava, Akanksha
Schroeder, Jan
Rossello, Fernando J.
Horvay, Katja
Prasko, Mirsada
Paynter, Jacob M.
Chen, Joseph
Weng, Chen-Fang
Sun, Yu B. Y.
Liu, Xiaodong
Chan, Eva
Deshpande, Nikita
Chen, Xiaoli
Li, Y. Jinhua
Pflueger, Jahnvi
Engel, Rebekah M.
Knaupp, Anja S.
Tsyganov, Kirill
Nilsson, Susan K.
Lister, Ryan
Rackham, Owen J. L.
Abud, Helen E.
Polo, Jose M.
author_facet Nefzger, Christian M.
Jardé, Thierry
Srivastava, Akanksha
Schroeder, Jan
Rossello, Fernando J.
Horvay, Katja
Prasko, Mirsada
Paynter, Jacob M.
Chen, Joseph
Weng, Chen-Fang
Sun, Yu B. Y.
Liu, Xiaodong
Chan, Eva
Deshpande, Nikita
Chen, Xiaoli
Li, Y. Jinhua
Pflueger, Jahnvi
Engel, Rebekah M.
Knaupp, Anja S.
Tsyganov, Kirill
Nilsson, Susan K.
Lister, Ryan
Rackham, Owen J. L.
Abud, Helen E.
Polo, Jose M.
author_sort Nefzger, Christian M.
collection PubMed
description The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
format Online
Article
Text
id pubmed-9203768
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92037682022-06-18 Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential Nefzger, Christian M. Jardé, Thierry Srivastava, Akanksha Schroeder, Jan Rossello, Fernando J. Horvay, Katja Prasko, Mirsada Paynter, Jacob M. Chen, Joseph Weng, Chen-Fang Sun, Yu B. Y. Liu, Xiaodong Chan, Eva Deshpande, Nikita Chen, Xiaoli Li, Y. Jinhua Pflueger, Jahnvi Engel, Rebekah M. Knaupp, Anja S. Tsyganov, Kirill Nilsson, Susan K. Lister, Ryan Rackham, Owen J. L. Abud, Helen E. Polo, Jose M. NPJ Regen Med Brief Communication The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs. Nature Publishing Group UK 2022-06-16 /pmc/articles/PMC9203768/ /pubmed/35710627 http://dx.doi.org/10.1038/s41536-022-00226-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Nefzger, Christian M.
Jardé, Thierry
Srivastava, Akanksha
Schroeder, Jan
Rossello, Fernando J.
Horvay, Katja
Prasko, Mirsada
Paynter, Jacob M.
Chen, Joseph
Weng, Chen-Fang
Sun, Yu B. Y.
Liu, Xiaodong
Chan, Eva
Deshpande, Nikita
Chen, Xiaoli
Li, Y. Jinhua
Pflueger, Jahnvi
Engel, Rebekah M.
Knaupp, Anja S.
Tsyganov, Kirill
Nilsson, Susan K.
Lister, Ryan
Rackham, Owen J. L.
Abud, Helen E.
Polo, Jose M.
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
title Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
title_full Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
title_fullStr Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
title_full_unstemmed Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
title_short Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
title_sort intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203768/
https://www.ncbi.nlm.nih.gov/pubmed/35710627
http://dx.doi.org/10.1038/s41536-022-00226-7
work_keys_str_mv AT nefzgerchristianm intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT jardethierry intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT srivastavaakanksha intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT schroederjan intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT rossellofernandoj intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT horvaykatja intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT praskomirsada intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT paynterjacobm intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT chenjoseph intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT wengchenfang intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT sunyuby intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT liuxiaodong intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT chaneva intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT deshpandenikita intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT chenxiaoli intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT liyjinhua intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT pfluegerjahnvi intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT engelrebekahm intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT knauppanjas intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT tsyganovkirill intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT nilssonsusank intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT listerryan intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT rackhamowenjl intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT abudhelene intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential
AT polojosem intestinalstemcellagingsignaturerevealsareprogrammingstrategytoenhanceregenerativepotential

Ejemplares similares