Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecula...

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Detalles Bibliográficos
Autores principales: Nefzger, Christian M., Jardé, Thierry, Srivastava, Akanksha, Schroeder, Jan, Rossello, Fernando J., Horvay, Katja, Prasko, Mirsada, Paynter, Jacob M., Chen, Joseph, Weng, Chen-Fang, Sun, Yu B. Y., Liu, Xiaodong, Chan, Eva, Deshpande, Nikita, Chen, Xiaoli, Li, Y. Jinhua, Pflueger, Jahnvi, Engel, Rebekah M., Knaupp, Anja S., Tsyganov, Kirill, Nilsson, Susan K., Lister, Ryan, Rackham, Owen J. L., Abud, Helen E., Polo, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203768/
https://www.ncbi.nlm.nih.gov/pubmed/35710627
http://dx.doi.org/10.1038/s41536-022-00226-7

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