A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

The airways and alveoli of the human respiratory tract are lined by two distinct types of epithelium, which are the primary targets of respiratory viruses. We previously established long-term expanding human lung epithelial organoids from lung tissues and developed a ‘proximal’ differentiation proto...

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Detalles Bibliográficos
Autores principales: Chiu, Man Chun, Li, Cun, Liu, Xiaojuan, Yu, Yifei, Huang, Jingjing, Wan, Zhixin, Xiao, Ding, Chu, Hin, Cai, Jian-Piao, Zhou, Biao, Sit, Ko-Yung, Au, Wing-Kuk, Wong, Kenneth Kak-Yuen, Li, Gang, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chen, Zhiwei, Jiang, Shibo, Clevers, Hans, Yuen, Kwok Yung, Zhou, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203776/
https://www.ncbi.nlm.nih.gov/pubmed/35710786
http://dx.doi.org/10.1038/s41421-022-00422-1

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