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Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis
Bronchiolisation and honeycombing are features of IPF. ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation. https://bit.ly/3i4dXeT
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Respiratory Society
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203838/ https://www.ncbi.nlm.nih.gov/pubmed/35604813 http://dx.doi.org/10.1183/13993003.02373-2021 |
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| author | Heinzelmann, Katharina Hu, Qianjiang Hu, Yan Dobrinskikh, Evgenia Ansari, Meshal Melo-Narváez, M. Camila Ulke, Henrik M. Leavitt, Colton Mirita, Carol Trudeau, Tammy Saal, Maxwell L. Rice, Pamela Gao, Bifeng Janssen, William J. Yang, Ivana V. Schiller, Herbert B. Vladar, Eszter K. Lehmann, Mareike Königshoff, Melanie |
| author_facet | Heinzelmann, Katharina Hu, Qianjiang Hu, Yan Dobrinskikh, Evgenia Ansari, Meshal Melo-Narváez, M. Camila Ulke, Henrik M. Leavitt, Colton Mirita, Carol Trudeau, Tammy Saal, Maxwell L. Rice, Pamela Gao, Bifeng Janssen, William J. Yang, Ivana V. Schiller, Herbert B. Vladar, Eszter K. Lehmann, Mareike Königshoff, Melanie |
| author_sort | Heinzelmann, Katharina |
| collection | PubMed |
| description | Bronchiolisation and honeycombing are features of IPF. ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation. https://bit.ly/3i4dXeT |
| format | Online Article Text |
| id | pubmed-9203838 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | European Respiratory Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92038382022-06-17 Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis Heinzelmann, Katharina Hu, Qianjiang Hu, Yan Dobrinskikh, Evgenia Ansari, Meshal Melo-Narváez, M. Camila Ulke, Henrik M. Leavitt, Colton Mirita, Carol Trudeau, Tammy Saal, Maxwell L. Rice, Pamela Gao, Bifeng Janssen, William J. Yang, Ivana V. Schiller, Herbert B. Vladar, Eszter K. Lehmann, Mareike Königshoff, Melanie Eur Respir J Agora Bronchiolisation and honeycombing are features of IPF. ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation. https://bit.ly/3i4dXeT European Respiratory Society 2022-06-16 /pmc/articles/PMC9203838/ /pubmed/35604813 http://dx.doi.org/10.1183/13993003.02373-2021 Text en Copyright ©The authors 2022. https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
| spellingShingle | Agora Heinzelmann, Katharina Hu, Qianjiang Hu, Yan Dobrinskikh, Evgenia Ansari, Meshal Melo-Narváez, M. Camila Ulke, Henrik M. Leavitt, Colton Mirita, Carol Trudeau, Tammy Saal, Maxwell L. Rice, Pamela Gao, Bifeng Janssen, William J. Yang, Ivana V. Schiller, Herbert B. Vladar, Eszter K. Lehmann, Mareike Königshoff, Melanie Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| title | Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| title_full | Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| title_fullStr | Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| title_full_unstemmed | Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| title_short | Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| title_sort | single-cell rna sequencing identifies g-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis |
| topic | Agora |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203838/ https://www.ncbi.nlm.nih.gov/pubmed/35604813 http://dx.doi.org/10.1183/13993003.02373-2021 |
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