Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis

Bronchiolisation and honeycombing are features of IPF. ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation. https://bit.ly/3i4dXeT

Detalles Bibliográficos
Autores principales: Heinzelmann, Katharina, Hu, Qianjiang, Hu, Yan, Dobrinskikh, Evgenia, Ansari, Meshal, Melo-Narváez, M. Camila, Ulke, Henrik M., Leavitt, Colton, Mirita, Carol, Trudeau, Tammy, Saal, Maxwell L., Rice, Pamela, Gao, Bifeng, Janssen, William J., Yang, Ivana V., Schiller, Herbert B., Vladar, Eszter K., Lehmann, Mareike, Königshoff, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Agora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203838/
https://www.ncbi.nlm.nih.gov/pubmed/35604813
http://dx.doi.org/10.1183/13993003.02373-2021

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