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Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition

PURPOSE: Tumor-microenvironment interactions are important determinants of drug resistance in colorectal cancer (CRC). We, therefore, set out to understand how interactions between genetically characterized CRC cells and stromal fibroblasts might influence response to molecularly targeted inhibitors...

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Detalles Bibliográficos
Autores principales:	Conciatori, Fabiana, Salvati, Erica, Ciuffreda, Ludovica, Shirasawa, Senji, Falcone, Italia, Cognetti, Francesco, Ferretti, Gianluigi, Zeuli, Massimo, Del Bufalo, Donatella, Bazzichetto, Chiara, Milella, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203999/ https://www.ncbi.nlm.nih.gov/pubmed/35719951 http://dx.doi.org/10.3389/fonc.2022.862806

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