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Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress
The poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) Olaparib is a widely used targeted therapy for a variety of solid tumors with homologous recombination deficiency (HRD) caused by mutation of BRCA1/2 or other DNA repair genes. The anti-tumor activity of Olaparib has been largely attributed t...
Autores principales: | Han, Tao, Tong, Jing, Wang, Mengxin, Gan, Yu, Gao, Bo, Chen, Jiaxiang, Liu, Youxun, Hao, Qian, Zhou, Xiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204002/ https://www.ncbi.nlm.nih.gov/pubmed/35719981 http://dx.doi.org/10.3389/fonc.2022.821366 |
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