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Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19

Nsp1 is one of the first proteins expressed from the SARS-CoV-2 genome and is a major virulence factor for COVID-19. A rapid multiplexed assay for detecting the action of Nsp1 was developed in cultured lung cells. The assay is based on the acute cytopathic effects induced by Nsp1. Virtual screening...

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Detalles Bibliográficos
Autores principales:	Kao, Hung-Teh, Orry, Andrew, Palfreyman, Michael G., Porton, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204075/ https://www.ncbi.nlm.nih.gov/pubmed/35715434 http://dx.doi.org/10.1038/s41598-022-14194-x

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