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Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions

ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engages in an antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm...

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Detalles Bibliográficos
Autores principales:	Biswas, Himadri, Zhao, Shu-Jun, Makinwa, Yetunde, Bassett, James S., Musich, Phillip R., Liu, Jing-Yuan, Zou, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204103/ https://www.ncbi.nlm.nih.gov/pubmed/35721505 http://dx.doi.org/10.3389/fcell.2022.826576

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