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Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission....
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204232/ https://www.ncbi.nlm.nih.gov/pubmed/35720401 http://dx.doi.org/10.3389/fimmu.2022.903903 |
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author | Gonçalves, Juan Jonathan da Mata, Camila Pacheco Silveira Martins Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos de Souza, Fernanda Mesquita Almeida, Vanessa Egídio Silveira Batista, Iara Antunes D`Avila-Mesquita, Carolina Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes de Melo Oliveira, Patrícia de Almeida Teixeira, Lorena Priscila de Almeida Marques, Daisymara Retes de Moraes, Henrique Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Campi-Azevedo, Ana Carolina Peruhype-Magalhães, Vanessa Araújo, Márcio Sobreira Silva Teixeira-Carvalho, Andréa da Fonseca, Flávio Guimarães Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Auxiliadora-Martins, Maria Coelho-dos-Reis, Jordana Grazziela Martins-Filho, Olindo Assis |
author_facet | Gonçalves, Juan Jonathan da Mata, Camila Pacheco Silveira Martins Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos de Souza, Fernanda Mesquita Almeida, Vanessa Egídio Silveira Batista, Iara Antunes D`Avila-Mesquita, Carolina Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes de Melo Oliveira, Patrícia de Almeida Teixeira, Lorena Priscila de Almeida Marques, Daisymara Retes de Moraes, Henrique Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Campi-Azevedo, Ana Carolina Peruhype-Magalhães, Vanessa Araújo, Márcio Sobreira Silva Teixeira-Carvalho, Andréa da Fonseca, Flávio Guimarães Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Auxiliadora-Martins, Maria Coelho-dos-Reis, Jordana Grazziela Martins-Filho, Olindo Assis |
author_sort | Gonçalves, Juan Jonathan |
collection | PubMed |
description | In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission. Augmented levels of soluble mediators were observed in serum from COVID-19 patients who progress to death. An opposite profile was observed in tracheal aspirate samples, indicating that systemic and airway microenvironment diverge in their inflammatory milieu. While a bimodal distribution was observed in the serum samples, a unimodal peak around D7 was found for most soluble mediators in tracheal aspirate samples. Systems biology tools further demonstrated that COVID-19 display distinct eccentric soluble mediator networks as compared to controls, with opposite profiles in serum and tracheal aspirates. Regardless the systemic-compartmentalized microenvironment, networks from patients progressing to death were linked to a pro-inflammatory/growth factor-rich, highly integrated center. Conversely, patients evolving to discharge exhibited networks of weak central architecture, with lower number of neighborhood connections and clusters of pro-inflammatory and regulatory cytokines. All in all, this investigation with robust sample size landed a comprehensive snapshot of the systemic and local divergencies composed of distinct immune responses driven by SARS-CoV-2 early on severe COVID-19. |
format | Online Article Text |
id | pubmed-9204232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92042322022-06-18 Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients Gonçalves, Juan Jonathan da Mata, Camila Pacheco Silveira Martins Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos de Souza, Fernanda Mesquita Almeida, Vanessa Egídio Silveira Batista, Iara Antunes D`Avila-Mesquita, Carolina Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes de Melo Oliveira, Patrícia de Almeida Teixeira, Lorena Priscila de Almeida Marques, Daisymara Retes de Moraes, Henrique Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Campi-Azevedo, Ana Carolina Peruhype-Magalhães, Vanessa Araújo, Márcio Sobreira Silva Teixeira-Carvalho, Andréa da Fonseca, Flávio Guimarães Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Auxiliadora-Martins, Maria Coelho-dos-Reis, Jordana Grazziela Martins-Filho, Olindo Assis Front Immunol Immunology In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission. Augmented levels of soluble mediators were observed in serum from COVID-19 patients who progress to death. An opposite profile was observed in tracheal aspirate samples, indicating that systemic and airway microenvironment diverge in their inflammatory milieu. While a bimodal distribution was observed in the serum samples, a unimodal peak around D7 was found for most soluble mediators in tracheal aspirate samples. Systems biology tools further demonstrated that COVID-19 display distinct eccentric soluble mediator networks as compared to controls, with opposite profiles in serum and tracheal aspirates. Regardless the systemic-compartmentalized microenvironment, networks from patients progressing to death were linked to a pro-inflammatory/growth factor-rich, highly integrated center. Conversely, patients evolving to discharge exhibited networks of weak central architecture, with lower number of neighborhood connections and clusters of pro-inflammatory and regulatory cytokines. All in all, this investigation with robust sample size landed a comprehensive snapshot of the systemic and local divergencies composed of distinct immune responses driven by SARS-CoV-2 early on severe COVID-19. Frontiers Media S.A. 2022-06-03 /pmc/articles/PMC9204232/ /pubmed/35720401 http://dx.doi.org/10.3389/fimmu.2022.903903 Text en Copyright © 2022 Gonçalves, da Mata, Lourenço, Ribeiro, Ferreira, Fraga-Silva, de Souza, Almeida, Batista, D`Avila-Mesquita, Couto, Campos, Paim, Ferreira, de Melo Oliveira, de Almeida Teixeira, Priscila de Almeida Marques, Retes de Moraes, Pereira, Brito-de-Sousa, Campi-Azevedo, Peruhype-Magalhães, Araújo, Teixeira-Carvalho, da Fonseca, Bonato, Becari, Ferro, Menegueti, Mazzoni, Auxiliadora-Martins, Coelho-dos-Reis and Martins-Filho https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gonçalves, Juan Jonathan da Mata, Camila Pacheco Silveira Martins Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos de Souza, Fernanda Mesquita Almeida, Vanessa Egídio Silveira Batista, Iara Antunes D`Avila-Mesquita, Carolina Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes de Melo Oliveira, Patrícia de Almeida Teixeira, Lorena Priscila de Almeida Marques, Daisymara Retes de Moraes, Henrique Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Campi-Azevedo, Ana Carolina Peruhype-Magalhães, Vanessa Araújo, Márcio Sobreira Silva Teixeira-Carvalho, Andréa da Fonseca, Flávio Guimarães Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Auxiliadora-Martins, Maria Coelho-dos-Reis, Jordana Grazziela Martins-Filho, Olindo Assis Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients |
title | Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients |
title_full | Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients |
title_fullStr | Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients |
title_full_unstemmed | Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients |
title_short | Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients |
title_sort | timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill covid-19 patients |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204232/ https://www.ncbi.nlm.nih.gov/pubmed/35720401 http://dx.doi.org/10.3389/fimmu.2022.903903 |
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