Cargando…

Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients

In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission....

Descripción completa

Detalles Bibliográficos
Autores principales: Gonçalves, Juan Jonathan, da Mata, Camila Pacheco Silveira Martins, Lourenço, Alice Aparecida, Ribeiro, Ágata Lopes, Ferreira, Geovane Marques, Fraga-Silva, Thais Fernanda de Campos, de Souza, Fernanda Mesquita, Almeida, Vanessa Egídio Silveira, Batista, Iara Antunes, D`Avila-Mesquita, Carolina, Couto, Ariel E. S., Campos, Ligia C. B., Paim, Adriana Alves Oliveira, Ferreira, Linziane Lopes, de Melo Oliveira, Patrícia, de Almeida Teixeira, Lorena, Priscila de Almeida Marques, Daisymara, Retes de Moraes, Henrique, Pereira, Samille Henriques, Brito-de-Sousa, Joaquim Pedro, Campi-Azevedo, Ana Carolina, Peruhype-Magalhães, Vanessa, Araújo, Márcio Sobreira Silva, Teixeira-Carvalho, Andréa, da Fonseca, Flávio Guimarães, Bonato, Vânia Luiza Deperon, Becari, Christiane, Ferro, Denise, Menegueti, Mayra Gonçalves, Mazzoni, Amanda Alves Silva, Auxiliadora-Martins, Maria, Coelho-dos-Reis, Jordana Grazziela, Martins-Filho, Olindo Assis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204232/
https://www.ncbi.nlm.nih.gov/pubmed/35720401
http://dx.doi.org/10.3389/fimmu.2022.903903
_version_ 1784728875122556928
author Gonçalves, Juan Jonathan
da Mata, Camila Pacheco Silveira Martins
Lourenço, Alice Aparecida
Ribeiro, Ágata Lopes
Ferreira, Geovane Marques
Fraga-Silva, Thais Fernanda de Campos
de Souza, Fernanda Mesquita
Almeida, Vanessa Egídio Silveira
Batista, Iara Antunes
D`Avila-Mesquita, Carolina
Couto, Ariel E. S.
Campos, Ligia C. B.
Paim, Adriana Alves Oliveira
Ferreira, Linziane Lopes
de Melo Oliveira, Patrícia
de Almeida Teixeira, Lorena
Priscila de Almeida Marques, Daisymara
Retes de Moraes, Henrique
Pereira, Samille Henriques
Brito-de-Sousa, Joaquim Pedro
Campi-Azevedo, Ana Carolina
Peruhype-Magalhães, Vanessa
Araújo, Márcio Sobreira Silva
Teixeira-Carvalho, Andréa
da Fonseca, Flávio Guimarães
Bonato, Vânia Luiza Deperon
Becari, Christiane
Ferro, Denise
Menegueti, Mayra Gonçalves
Mazzoni, Amanda Alves Silva
Auxiliadora-Martins, Maria
Coelho-dos-Reis, Jordana Grazziela
Martins-Filho, Olindo Assis
author_facet Gonçalves, Juan Jonathan
da Mata, Camila Pacheco Silveira Martins
Lourenço, Alice Aparecida
Ribeiro, Ágata Lopes
Ferreira, Geovane Marques
Fraga-Silva, Thais Fernanda de Campos
de Souza, Fernanda Mesquita
Almeida, Vanessa Egídio Silveira
Batista, Iara Antunes
D`Avila-Mesquita, Carolina
Couto, Ariel E. S.
Campos, Ligia C. B.
Paim, Adriana Alves Oliveira
Ferreira, Linziane Lopes
de Melo Oliveira, Patrícia
de Almeida Teixeira, Lorena
Priscila de Almeida Marques, Daisymara
Retes de Moraes, Henrique
Pereira, Samille Henriques
Brito-de-Sousa, Joaquim Pedro
Campi-Azevedo, Ana Carolina
Peruhype-Magalhães, Vanessa
Araújo, Márcio Sobreira Silva
Teixeira-Carvalho, Andréa
da Fonseca, Flávio Guimarães
Bonato, Vânia Luiza Deperon
Becari, Christiane
Ferro, Denise
Menegueti, Mayra Gonçalves
Mazzoni, Amanda Alves Silva
Auxiliadora-Martins, Maria
Coelho-dos-Reis, Jordana Grazziela
Martins-Filho, Olindo Assis
author_sort Gonçalves, Juan Jonathan
collection PubMed
description In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission. Augmented levels of soluble mediators were observed in serum from COVID-19 patients who progress to death. An opposite profile was observed in tracheal aspirate samples, indicating that systemic and airway microenvironment diverge in their inflammatory milieu. While a bimodal distribution was observed in the serum samples, a unimodal peak around D7 was found for most soluble mediators in tracheal aspirate samples. Systems biology tools further demonstrated that COVID-19 display distinct eccentric soluble mediator networks as compared to controls, with opposite profiles in serum and tracheal aspirates. Regardless the systemic-compartmentalized microenvironment, networks from patients progressing to death were linked to a pro-inflammatory/growth factor-rich, highly integrated center. Conversely, patients evolving to discharge exhibited networks of weak central architecture, with lower number of neighborhood connections and clusters of pro-inflammatory and regulatory cytokines. All in all, this investigation with robust sample size landed a comprehensive snapshot of the systemic and local divergencies composed of distinct immune responses driven by SARS-CoV-2 early on severe COVID-19.
format Online
Article
Text
id pubmed-9204232
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92042322022-06-18 Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients Gonçalves, Juan Jonathan da Mata, Camila Pacheco Silveira Martins Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos de Souza, Fernanda Mesquita Almeida, Vanessa Egídio Silveira Batista, Iara Antunes D`Avila-Mesquita, Carolina Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes de Melo Oliveira, Patrícia de Almeida Teixeira, Lorena Priscila de Almeida Marques, Daisymara Retes de Moraes, Henrique Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Campi-Azevedo, Ana Carolina Peruhype-Magalhães, Vanessa Araújo, Márcio Sobreira Silva Teixeira-Carvalho, Andréa da Fonseca, Flávio Guimarães Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Auxiliadora-Martins, Maria Coelho-dos-Reis, Jordana Grazziela Martins-Filho, Olindo Assis Front Immunol Immunology In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission. Augmented levels of soluble mediators were observed in serum from COVID-19 patients who progress to death. An opposite profile was observed in tracheal aspirate samples, indicating that systemic and airway microenvironment diverge in their inflammatory milieu. While a bimodal distribution was observed in the serum samples, a unimodal peak around D7 was found for most soluble mediators in tracheal aspirate samples. Systems biology tools further demonstrated that COVID-19 display distinct eccentric soluble mediator networks as compared to controls, with opposite profiles in serum and tracheal aspirates. Regardless the systemic-compartmentalized microenvironment, networks from patients progressing to death were linked to a pro-inflammatory/growth factor-rich, highly integrated center. Conversely, patients evolving to discharge exhibited networks of weak central architecture, with lower number of neighborhood connections and clusters of pro-inflammatory and regulatory cytokines. All in all, this investigation with robust sample size landed a comprehensive snapshot of the systemic and local divergencies composed of distinct immune responses driven by SARS-CoV-2 early on severe COVID-19. Frontiers Media S.A. 2022-06-03 /pmc/articles/PMC9204232/ /pubmed/35720401 http://dx.doi.org/10.3389/fimmu.2022.903903 Text en Copyright © 2022 Gonçalves, da Mata, Lourenço, Ribeiro, Ferreira, Fraga-Silva, de Souza, Almeida, Batista, D`Avila-Mesquita, Couto, Campos, Paim, Ferreira, de Melo Oliveira, de Almeida Teixeira, Priscila de Almeida Marques, Retes de Moraes, Pereira, Brito-de-Sousa, Campi-Azevedo, Peruhype-Magalhães, Araújo, Teixeira-Carvalho, da Fonseca, Bonato, Becari, Ferro, Menegueti, Mazzoni, Auxiliadora-Martins, Coelho-dos-Reis and Martins-Filho https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gonçalves, Juan Jonathan
da Mata, Camila Pacheco Silveira Martins
Lourenço, Alice Aparecida
Ribeiro, Ágata Lopes
Ferreira, Geovane Marques
Fraga-Silva, Thais Fernanda de Campos
de Souza, Fernanda Mesquita
Almeida, Vanessa Egídio Silveira
Batista, Iara Antunes
D`Avila-Mesquita, Carolina
Couto, Ariel E. S.
Campos, Ligia C. B.
Paim, Adriana Alves Oliveira
Ferreira, Linziane Lopes
de Melo Oliveira, Patrícia
de Almeida Teixeira, Lorena
Priscila de Almeida Marques, Daisymara
Retes de Moraes, Henrique
Pereira, Samille Henriques
Brito-de-Sousa, Joaquim Pedro
Campi-Azevedo, Ana Carolina
Peruhype-Magalhães, Vanessa
Araújo, Márcio Sobreira Silva
Teixeira-Carvalho, Andréa
da Fonseca, Flávio Guimarães
Bonato, Vânia Luiza Deperon
Becari, Christiane
Ferro, Denise
Menegueti, Mayra Gonçalves
Mazzoni, Amanda Alves Silva
Auxiliadora-Martins, Maria
Coelho-dos-Reis, Jordana Grazziela
Martins-Filho, Olindo Assis
Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
title Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
title_full Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
title_fullStr Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
title_full_unstemmed Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
title_short Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients
title_sort timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill covid-19 patients
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204232/
https://www.ncbi.nlm.nih.gov/pubmed/35720401
http://dx.doi.org/10.3389/fimmu.2022.903903
work_keys_str_mv AT goncalvesjuanjonathan timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT damatacamilapachecosilveiramartins timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT lourencoaliceaparecida timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT ribeiroagatalopes timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT ferreirageovanemarques timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT fragasilvathaisfernandadecampos timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT desouzafernandamesquita timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT almeidavanessaegidiosilveira timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT batistaiaraantunes timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT davilamesquitacarolina timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT coutoarieles timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT camposligiacb timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT paimadrianaalvesoliveira timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT ferreiralinzianelopes timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT demelooliveirapatricia timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT dealmeidateixeiralorena timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT prisciladealmeidamarquesdaisymara timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT retesdemoraeshenrique timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT pereirasamillehenriques timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT britodesousajoaquimpedro timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT campiazevedoanacarolina timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT peruhypemagalhaesvanessa timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT araujomarciosobreirasilva timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT teixeiracarvalhoandrea timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT dafonsecaflavioguimaraes timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT bonatovanialuizadeperon timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT becarichristiane timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT ferrodenise timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT meneguetimayragoncalves timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT mazzoniamandaalvessilva timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT auxiliadoramartinsmaria timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT coelhodosreisjordanagrazziela timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients
AT martinsfilhoolindoassis timelinekineticsofsystemicandairwayimmunemediatorstormforcomprehensiveanalysisofdiseaseoutcomeincriticallyillcovid19patients