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Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis
Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. Th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204246/ https://www.ncbi.nlm.nih.gov/pubmed/35722347 http://dx.doi.org/10.3389/fmicb.2022.894283 |
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author | Wenhui, Yu Zhongyu, Xie Kai, Chen Zhaopeng, Cai Jinteng, Li Mengjun, Ma Zepeng, Su Yunshu, Che Peng, Wang Yanfeng, Wu Huiyong, Shen |
author_facet | Wenhui, Yu Zhongyu, Xie Kai, Chen Zhaopeng, Cai Jinteng, Li Mengjun, Ma Zepeng, Su Yunshu, Che Peng, Wang Yanfeng, Wu Huiyong, Shen |
author_sort | Wenhui, Yu |
collection | PubMed |
description | Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. The gut microbiota is indispensable for internal homeostasis and regulates various biological processes. Understanding the gut microbiota profiles in normal controls (NCs), breast cancer patients with no metastasis (BNs), and breast cancer patients with bone metastasis (BMs) may shed light on the development of diagnostic and therapeutic targets for breast cancer and bone metastasis. We comprehensively analyzed the gut microbiota from NCs, BNs, and BMs and found that the community diversity decreased in the order of NCs, BNs, and BMs. Streptococcus, Campylobacter and Moraxellaceae showed higher abundances in BNs and BMs than in NCs. The lack of Megamonas and Akkermansia in the BM compared with those in the NC and BN groups was considered related to bone metastasis. Additionally, based on the distinct gut microbiota profiles, we predicted that lipid transportation and metabolism, as well as folate biosynthesis, participate in breast cancer occurrence and that steroid hormone biosynthesis influences bone metastasis. Our study demonstrated that variations in gut microbiota are associated with breast cancer occurrence and bone metastasis, providing attractive targets to develop therapeutic and diagnostic methods. |
format | Online Article Text |
id | pubmed-9204246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92042462022-06-18 Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis Wenhui, Yu Zhongyu, Xie Kai, Chen Zhaopeng, Cai Jinteng, Li Mengjun, Ma Zepeng, Su Yunshu, Che Peng, Wang Yanfeng, Wu Huiyong, Shen Front Microbiol Microbiology Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. The gut microbiota is indispensable for internal homeostasis and regulates various biological processes. Understanding the gut microbiota profiles in normal controls (NCs), breast cancer patients with no metastasis (BNs), and breast cancer patients with bone metastasis (BMs) may shed light on the development of diagnostic and therapeutic targets for breast cancer and bone metastasis. We comprehensively analyzed the gut microbiota from NCs, BNs, and BMs and found that the community diversity decreased in the order of NCs, BNs, and BMs. Streptococcus, Campylobacter and Moraxellaceae showed higher abundances in BNs and BMs than in NCs. The lack of Megamonas and Akkermansia in the BM compared with those in the NC and BN groups was considered related to bone metastasis. Additionally, based on the distinct gut microbiota profiles, we predicted that lipid transportation and metabolism, as well as folate biosynthesis, participate in breast cancer occurrence and that steroid hormone biosynthesis influences bone metastasis. Our study demonstrated that variations in gut microbiota are associated with breast cancer occurrence and bone metastasis, providing attractive targets to develop therapeutic and diagnostic methods. Frontiers Media S.A. 2022-05-26 /pmc/articles/PMC9204246/ /pubmed/35722347 http://dx.doi.org/10.3389/fmicb.2022.894283 Text en Copyright © 2022 Wenhui, Zhongyu, Kai, Zhaopeng, Jinteng, Mengjun, Zepeng, Yunshu, Peng, Yanfeng and Huiyong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Wenhui, Yu Zhongyu, Xie Kai, Chen Zhaopeng, Cai Jinteng, Li Mengjun, Ma Zepeng, Su Yunshu, Che Peng, Wang Yanfeng, Wu Huiyong, Shen Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
title | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
title_full | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
title_fullStr | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
title_full_unstemmed | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
title_short | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
title_sort | variations in the gut microbiota in breast cancer occurrence and bone metastasis |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204246/ https://www.ncbi.nlm.nih.gov/pubmed/35722347 http://dx.doi.org/10.3389/fmicb.2022.894283 |
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