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Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties
SIGNIFICANCE: The shortwave infrared (SWIR) optical window (∼900 to 2000 nm) has attracted interest for deep tissue imaging due to the lower scattering of light. SWIR spatial frequency domain imaging (SWIR SFDI) provides wide-field tissue optical property measurements in this wavelength band. Key de...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204261/ https://www.ncbi.nlm.nih.gov/pubmed/35715883 http://dx.doi.org/10.1117/1.JBO.27.6.066003 |
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author | Pilvar, Anahita Plutzky, Jorge Pierce, Mark C. Roblyer, Darren |
author_facet | Pilvar, Anahita Plutzky, Jorge Pierce, Mark C. Roblyer, Darren |
author_sort | Pilvar, Anahita |
collection | PubMed |
description | SIGNIFICANCE: The shortwave infrared (SWIR) optical window (∼900 to 2000 nm) has attracted interest for deep tissue imaging due to the lower scattering of light. SWIR spatial frequency domain imaging (SWIR SFDI) provides wide-field tissue optical property measurements in this wavelength band. Key design and performance characteristics, such as portability, wavelength selection, measurement resolution, and the effect of skin have not yet been addressed for SWIR SFDI. AIM: To fabricate and characterize a SWIR SFDI system for clinical use. APPROACH: The optimal choice of wavelengths was identified based on optical property uncertainty estimates and imaging depth. A compact light-emitting diode-based dual wavelength SWIR SFDI system was fabricated. A two-layer inverse model was developed to account for the layered structure of skin. Performance was validated using tissue-simulating phantoms and in-vivo measurements from three healthy subjects. RESULTS: The SWIR SFDI system had a [Formula: see text] resolution of at least [Formula: see text] at 880 nm and [Formula: see text] at 1100 nm. The two-layer inverse model reduced the error in deeper layer [Formula: see text] extractions by at least 24% in the phantom study. The two-layer model also increased the contrast between superficial vessels and the surrounding tissue for in-vivo measurements. CONCLUSION: The clinic-ready SWIR SFDI device is sensitive to small optical property alterations in diffuse media, provides enhanced accuracy in quantifying optical properties in the deeper layers in phantoms, and provided enhanced contrast of subcutaneous blood vessels. |
format | Online Article Text |
id | pubmed-9204261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society of Photo-Optical Instrumentation Engineers |
record_format | MEDLINE/PubMed |
spelling | pubmed-92042612022-06-17 Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties Pilvar, Anahita Plutzky, Jorge Pierce, Mark C. Roblyer, Darren J Biomed Opt Imaging SIGNIFICANCE: The shortwave infrared (SWIR) optical window (∼900 to 2000 nm) has attracted interest for deep tissue imaging due to the lower scattering of light. SWIR spatial frequency domain imaging (SWIR SFDI) provides wide-field tissue optical property measurements in this wavelength band. Key design and performance characteristics, such as portability, wavelength selection, measurement resolution, and the effect of skin have not yet been addressed for SWIR SFDI. AIM: To fabricate and characterize a SWIR SFDI system for clinical use. APPROACH: The optimal choice of wavelengths was identified based on optical property uncertainty estimates and imaging depth. A compact light-emitting diode-based dual wavelength SWIR SFDI system was fabricated. A two-layer inverse model was developed to account for the layered structure of skin. Performance was validated using tissue-simulating phantoms and in-vivo measurements from three healthy subjects. RESULTS: The SWIR SFDI system had a [Formula: see text] resolution of at least [Formula: see text] at 880 nm and [Formula: see text] at 1100 nm. The two-layer inverse model reduced the error in deeper layer [Formula: see text] extractions by at least 24% in the phantom study. The two-layer model also increased the contrast between superficial vessels and the surrounding tissue for in-vivo measurements. CONCLUSION: The clinic-ready SWIR SFDI device is sensitive to small optical property alterations in diffuse media, provides enhanced accuracy in quantifying optical properties in the deeper layers in phantoms, and provided enhanced contrast of subcutaneous blood vessels. Society of Photo-Optical Instrumentation Engineers 2022-06-17 2022-06 /pmc/articles/PMC9204261/ /pubmed/35715883 http://dx.doi.org/10.1117/1.JBO.27.6.066003 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
spellingShingle | Imaging Pilvar, Anahita Plutzky, Jorge Pierce, Mark C. Roblyer, Darren Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
title | Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
title_full | Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
title_fullStr | Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
title_full_unstemmed | Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
title_short | Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
title_sort | shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties |
topic | Imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204261/ https://www.ncbi.nlm.nih.gov/pubmed/35715883 http://dx.doi.org/10.1117/1.JBO.27.6.066003 |
work_keys_str_mv | AT pilvaranahita shortwaveinfraredspatialfrequencydomainimagingfornoninvasivemeasurementoftissueandbloodopticalproperties AT plutzkyjorge shortwaveinfraredspatialfrequencydomainimagingfornoninvasivemeasurementoftissueandbloodopticalproperties AT piercemarkc shortwaveinfraredspatialfrequencydomainimagingfornoninvasivemeasurementoftissueandbloodopticalproperties AT roblyerdarren shortwaveinfraredspatialfrequencydomainimagingfornoninvasivemeasurementoftissueandbloodopticalproperties |