Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints, amongst which are a set of deubiquitinating protea...

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Detalles Bibliográficos
Autores principales: Hameed, Dharjath S., Ovaa, Huib, van der Heden van Noort, Gerbrand J., Sapmaz, Aysegul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204298/
https://www.ncbi.nlm.nih.gov/pubmed/35720124
http://dx.doi.org/10.3389/fmolb.2022.866467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204298/
https://www.ncbi.nlm.nih.gov/pubmed/35720124
http://dx.doi.org/10.3389/fmolb.2022.866467

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