Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation

Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 1...

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Detalles Bibliográficos
Autores principales: Alteri, Claudia, Scutari, Rossana, Costabile, Valentino, Colagrossi, Luna, Yu La Rosa, Katia, Agolini, Emanuele, Lanari, Valentina, Chiurchiù, Sara, Romani, Lorenza, Markowich, Anna Hermine, Bernaschi, Paola, Russo, Cristina, Novelli, Antonio, Bernardi, Stefania, Campana, Andrea, Villani, Alberto, Perno, Carlo Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204374/
https://www.ncbi.nlm.nih.gov/pubmed/35715488
http://dx.doi.org/10.1038/s41598-022-14426-0
Descripción
Sumario:Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.

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