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Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation
Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 1...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204374/ https://www.ncbi.nlm.nih.gov/pubmed/35715488 http://dx.doi.org/10.1038/s41598-022-14426-0 |
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| author | Alteri, Claudia Scutari, Rossana Costabile, Valentino Colagrossi, Luna Yu La Rosa, Katia Agolini, Emanuele Lanari, Valentina Chiurchiù, Sara Romani, Lorenza Markowich, Anna Hermine Bernaschi, Paola Russo, Cristina Novelli, Antonio Bernardi, Stefania Campana, Andrea Villani, Alberto Perno, Carlo Federico |
| author_facet | Alteri, Claudia Scutari, Rossana Costabile, Valentino Colagrossi, Luna Yu La Rosa, Katia Agolini, Emanuele Lanari, Valentina Chiurchiù, Sara Romani, Lorenza Markowich, Anna Hermine Bernaschi, Paola Russo, Cristina Novelli, Antonio Bernardi, Stefania Campana, Andrea Villani, Alberto Perno, Carlo Federico |
| author_sort | Alteri, Claudia |
| collection | PubMed |
| description | Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization. |
| format | Online Article Text |
| id | pubmed-9204374 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92043742022-06-17 Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation Alteri, Claudia Scutari, Rossana Costabile, Valentino Colagrossi, Luna Yu La Rosa, Katia Agolini, Emanuele Lanari, Valentina Chiurchiù, Sara Romani, Lorenza Markowich, Anna Hermine Bernaschi, Paola Russo, Cristina Novelli, Antonio Bernardi, Stefania Campana, Andrea Villani, Alberto Perno, Carlo Federico Sci Rep Article Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization. Nature Publishing Group UK 2022-06-17 /pmc/articles/PMC9204374/ /pubmed/35715488 http://dx.doi.org/10.1038/s41598-022-14426-0 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Alteri, Claudia Scutari, Rossana Costabile, Valentino Colagrossi, Luna Yu La Rosa, Katia Agolini, Emanuele Lanari, Valentina Chiurchiù, Sara Romani, Lorenza Markowich, Anna Hermine Bernaschi, Paola Russo, Cristina Novelli, Antonio Bernardi, Stefania Campana, Andrea Villani, Alberto Perno, Carlo Federico Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation |
| title | Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation |
| title_full | Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation |
| title_fullStr | Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation |
| title_full_unstemmed | Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation |
| title_short | Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation |
| title_sort | epidemiological characterization of sars-cov-2 variants in children over the four covid-19 waves and correlation with clinical presentation |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204374/ https://www.ncbi.nlm.nih.gov/pubmed/35715488 http://dx.doi.org/10.1038/s41598-022-14426-0 |
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