Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer

BACKGROUND: Gastrointestinal (GI) cancer is the second most common cancer type with mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) phenotype that is expected to respond to immune-checkpoint inhibitors (ICIs). However, approximately half of the patients with dMMR/MSI-H GI ca...

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Detalles Bibliográficos
Autores principales: Wang, Zhenghang, Zhang, Qi, Qi, Changsong, Bai, Yuezong, Zhao, Feilong, Chen, Hui, Li, Zhongwu, Wang, Xicheng, Chen, Mifen, Gong, Jifang, Peng, Zhi, Zhang, Xiaotian, Cai, Jinping, Chen, Shiqing, Zhao, Xiaochen, Shen, Lin, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204428/
https://www.ncbi.nlm.nih.gov/pubmed/35705314
http://dx.doi.org/10.1136/jitc-2022-004703

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